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10.1126/science.1215930 http://scihub22266oqcxt.onion/10.1126/science.1215930 C5367627!5367627!22267811     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2012 ; 335 (6066): 332-5 Nephropedia Template TP {{tp|p=22267811|t=2012. Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis |pdf=|usr=}}{{22267811}} gab.com Text Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=22267811 #FOAvip Infections with Shiga toxin (STx)?producing bacteria cause more than a million deaths each year and have no definitive treatment. To exert its cytotoxic effect, STx invades cells through retrograde membrane trafficking, escaping the lysosomal degradative pathway. We found that the widely available metal manganese (Mn2+) blocked endosome-to-Golgi trafficking of STx and caused its degradation in lysosomes. Mn2+ targeted the cycling Golgi protein GPP130, which STx bound in control cells during sorting into Golgi-directed endosomal tubules that bypass lysosomes. In tissue culture cells, treatment with Mn2+ yielded a protection factor of 3800 against STx-induced cell death. Furthermore, mice injected with nontoxic doses of Mn2+ were completely resistant to a lethal STx challenge. Thus, Mn2+ may represent a low-cost therapeutic agent for the treatment of STx infections. Twit Text FOAVip Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis ????Science http://www.kidney.de/pget.php?&tw=1&pmid=22267811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22267811 #FOAvip English Wikipedia <ref>{{Cite pmid|22267811}}</ref> Manganese Blocks Intracellular Trafficking of Shiga Toxin and Protects Against Shiga Toxicosis #MMPMID22267811 Mukhopadhyay S; Linstedt AD Science 2012[Jan]; 335 (6066): 332-5 PMID22267811show ga Infections with Shiga toxin (STx)?producing bacteria cause more than a million deaths each year and have no definitive treatment. To exert its cytotoxic effect, STx invades cells through retrograde membrane trafficking, escaping the lysosomal degradative pathway. We found that the widely available metal manganese (Mn2+) blocked endosome-to-Golgi trafficking of STx and caused its degradation in lysosomes. Mn2+ targeted the cycling Golgi protein GPP130, which STx bound in control cells during sorting into Golgi-directed endosomal tubules that bypass lysosomes. In tissue culture cells, treatment with Mn2+ yielded a protection factor of 3800 against STx-induced cell death. Furthermore, mice injected with nontoxic doses of Mn2+ were completely resistant to a lethal STx challenge. Thus, Mn2+ may represent a low-cost therapeutic agent for the treatment of STx infections. äManganese Blocks Intracellular Trafficking of Shiga Toxin and Protects(epmc).pdf DeepDyve Pubget Overpricing