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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 EFORT+Open+Rev
2016 ; 1
(4
): 89-99
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gab.com Text
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Orthopaedic device-related infection: current and future interventions for
improved prevention and treatment
#MMPMID28461934
Moriarty TF
; Kuehl R
; Coenye T
; Metsemakers WJ
; Morgenstern M
; Schwarz EM
; Riool M
; Zaat SAJ
; Khana N
; Kates SL
; Richards RG
EFORT Open Rev
2016[Apr]; 1
(4
): 89-99
PMID28461934
show ga
Orthopaedic and trauma device-related infection (ODRI) remains one of the major
complications in modern trauma and orthopaedic surgery.Despite best practice in
medical and surgical management, neither prophylaxis nor treatment of ODRI is
effective in all cases, leading to infections that negatively impact clinical
outcome and significantly increase healthcare expenditure.The following review
summarises the microbiological profile of modern ODRI, the impact antibiotic
resistance has on treatment outcomes, and some of the principles and weaknesses
of the current systemic and local antibiotic delivery strategies.The emerging
novel strategies aimed at preventing or treating ODRI will be reviewed.
Particular attention will be paid to the potential for clinical impact in the
coming decades, when such interventions are likely to be critically important.The
review focuses on this problem from an interdisciplinary perspective, including
basic science innovations and best practice in infectious disease. Cite this
article: Moriarty TF, Kuehl R, Coenye T, et al. Orthopaedic device related
infection: current and future interventions for improved prevention and
treatment. EFORT Open Rev 2016;1:89-99. DOI: 10.1302/2058-5241.1.000037.