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10.1016/j.jaac.2017.01.013 http://scihub22266oqcxt.onion/10.1016/j.jaac.2017.01.013 C5367472!5367472!28335876     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Acad+Child+Adolesc+Psychiatry 2017 ; 56 (4): 321-328.e1 Nephropedia Template TP {{tp|p=28335876|t=2017. Child Abuse, Neural Structure, and Adolescent Psychopathology: A Longitudinal Study |pdf=|usr=}}{{28335876}} gab.com Text Child Abuse, Neural Structure, and Adolescent Psychopathology: A Longitudinal Study JO: J Am Acad Child Adolesc Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=28335876 #FOAvip Objective: Child abuse exerts a deleterious impact on a broad array of mental health outcomes. However, the neurobiological mechanisms that mediate this association remain poorly characterized. Here, we use a longitudinal design to prospectively identify neural mediators of the association between child abuse and psychiatric disorders in a community sample of adolescents. Method: Structural magnetic resonance imaging (MRI) data and assessments of mental health were acquired for 51 adolescents (aged 13?20; M=16.96; SD=1.51), 19 of whom were exposed to physical or sexual abuse. Participants were assessed for abuse exposure (Time 1), participated in MRI scanning and a diagnostic structured interview (Time 2), and two years later were followed-up to assess psychopathology (Time 3). We examined associations between child abuse and neural structure, and identified whether abuse-related differences in neural structure prospectively predicted psychiatric symptoms. Results: Abuse was associated with reduced cortical thickness in medial and lateral prefrontal and temporal lobe regions. Thickness of the left and right parahippocampal gyrus predicted antisocial behavior symptoms, and thickness of the middle temporal gyrus predicted symptoms of generalized anxiety disorder. Thickness of the left parahippocampal gyrus mediated the longitudinal association of abuse with antisocial behavior. Conclusion: Child abuse is associated with widespread disruptions in cortical structure, and these disruptions are selectively associated with increased vulnerability to internalizing and externalizing psychopathology. Identifying predictive biomarkers of vulnerability following childhood maltreatment may uncover neurodevelopmental mechanisms linking environmental experience with the onset of psychopathology. Twit Text FOAVip Child Abuse, Neural Structure, and Adolescent Psychopathology: A Longitudinal Study ????J Am Acad Child Adolesc Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=28335876 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28335876 #FOAvip English Wikipedia <ref>{{Cite pmid|28335876}}</ref> Child Abuse, Neural Structure, and Adolescent Psychopathology: A Longitudinal Study #MMPMID28335876 Busso DS; McLaughlin KA; Brueck S; Peverill M; Gold AL; Sheridan MA J Am Acad Child Adolesc Psychiatry 2017[Apr]; 56 (4): 321-328.e1 PMID28335876show ga Objective: Child abuse exerts a deleterious impact on a broad array of mental health outcomes. However, the neurobiological mechanisms that mediate this association remain poorly characterized. Here, we use a longitudinal design to prospectively identify neural mediators of the association between child abuse and psychiatric disorders in a community sample of adolescents. Method: Structural magnetic resonance imaging (MRI) data and assessments of mental health were acquired for 51 adolescents (aged 13?20; M=16.96; SD=1.51), 19 of whom were exposed to physical or sexual abuse. Participants were assessed for abuse exposure (Time 1), participated in MRI scanning and a diagnostic structured interview (Time 2), and two years later were followed-up to assess psychopathology (Time 3). We examined associations between child abuse and neural structure, and identified whether abuse-related differences in neural structure prospectively predicted psychiatric symptoms. Results: Abuse was associated with reduced cortical thickness in medial and lateral prefrontal and temporal lobe regions. Thickness of the left and right parahippocampal gyrus predicted antisocial behavior symptoms, and thickness of the middle temporal gyrus predicted symptoms of generalized anxiety disorder. Thickness of the left parahippocampal gyrus mediated the longitudinal association of abuse with antisocial behavior. Conclusion: Child abuse is associated with widespread disruptions in cortical structure, and these disruptions are selectively associated with increased vulnerability to internalizing and externalizing psychopathology. Identifying predictive biomarkers of vulnerability following childhood maltreatment may uncover neurodevelopmental mechanisms linking environmental experience with the onset of psychopathology. äChild Abuse, Neural Structure, and Adolescent Psychopathology: A Longi(epmc).pdf DeepDyve Pubget Overpricing