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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Adv+Virus+Res
2017 ; 97
(ä): 107-141
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Have NEC Coat, Will Travel: Structural Basis of Membrane Budding During Nuclear
Egress in Herpesviruses
#MMPMID28057257
Bigalke JM
; Heldwein EE
Adv Virus Res
2017[]; 97
(ä): 107-141
PMID28057257
show ga
Herpesviruses are unusual among enveloped viruses because they bud twice yet
acquire a single envelope. Furthermore, unlike other DNA viruses that replicate
in the nucleus, herpesviruses do not exit it by passing through the nuclear pores
or by rupturing the nuclear envelope. Instead, herpesviruses have a complex
mechanism of nuclear escape whereby nascent capsids bud at the inner nuclear
membrane to form perinuclear virions that subsequently fuse with the outer
nuclear membrane, releasing capsids into the cytosol. This makes them some of the
very few known viruses that bud into the nuclear envelope. The envelope acquired
during nuclear budding does not end up in the mature viral particle but instead
allows the capsid to translocate from the nucleus into the cytosol. The viral
nuclear egress complex (NEC) is a critical player in the nuclear egress, yet its
function and mechanism have remained enigmatic. Recent studies have demonstrated
that the NEC buds membranes without the help of other proteins by forming a
honeycomb coat, which established the NEC as the first virally encoded budding
machine that operates at the nuclear, as opposed to cytoplasmic, membrane. This
review discusses our current understanding of the NEC budding mechanism, with the
emphasis on studies that illuminated the structure of the NEC coat and its role
in capsid budding during herpesvirus nuclear escape.
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