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10.3892/mmr.2017.6103 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6103 C5367370!5367370 !28075469     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28075469 &cmd=llinks): Failed to open stream: HTTP request failed! 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Urinary kidney injury molecule?1 as an early diagnostic biomarker of obstructive acute kidney injury and development of a rapid detection method |pdf=|usr=}}{{28075469 }} gab.com Text Urinary kidney injury molecule 1 as an early diagnostic biomarker of obstructive acute kidney injury and development of a rapid detection method JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28075469 #FOAvip The aim of the present study was to investigate whether urinary kidney injury molecule?1 (KIM?1) presents a suitable early diagnostic biomarker of obstructive nephropathy?induced acute kidney injury (AKI), and to develop a rapid detection method for urinary KIM?1. Obstructive AKI was induced in an experimental rat model by a unilateral ureteral obstruction (UUO) operation. Macro? and micromorphological kidney alterations were determined by visual observation and hematoxylin and eosin (HE) staining, respectively. Kidney functions were evaluated by detecting urea nitrogen and creatinine levels in rat urine and blood. Urinary KIM?1 levels were measured using an enzyme?linked immunosorbent assay, and the protein expression levels of KIM?1, ??smooth muscle actin (??SMA) and vimentin in kidney tissues were detected using immunohistochemical assays. In order to measure KIM?1 levels, colloidal gold immunochromatographic strips were developed based on the colloidal gold immunochromatographic assay. The results indicated that KIM?1 levels were significantly higher in the UUO group when compared with the Sham group. KIM?1 levels in the urine and kidney tissues exhibited a time?dependent increase, together with increasing obstructive AKI in the UUO group. In addition, KIM?1 levels were demonstrated to be a more sensitive biomarker of early obstructive AKI, when compared with ??SMA and vimentin. A colloidal gold?based immunochromatographic strip was developed, whereby the detection of urinary KIM?1 could be completed within 5?10 min. In conclusion, results of the present study demonstrated that urinary KIM?1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM?1. Twit Text FOAVip Urinary kidney injury molecule 1 as an early diagnostic biomarker of obstructive acute kidney injury and development of a rapid detection method ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28075469 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28075469 #FOAvip English Wikipedia <ref>{{Cite pmid|28075469 }}</ref> Urinary kidney injury molecule?1 as an early diagnostic biomarker of obstructive acute kidney injury and development of a rapid detection method #MMPMID28075469 Jin Y ; Shao X ; Sun B ; Miao C ; Li Z ; Shi Y Mol Med Rep 2017[Mar]; 15 (3 ): 1229-1235 PMID28075469 show ga The aim of the present study was to investigate whether urinary kidney injury molecule?1 (KIM?1) presents a suitable early diagnostic biomarker of obstructive nephropathy?induced acute kidney injury (AKI), and to develop a rapid detection method for urinary KIM?1. Obstructive AKI was induced in an experimental rat model by a unilateral ureteral obstruction (UUO) operation. Macro? and micromorphological kidney alterations were determined by visual observation and hematoxylin and eosin (HE) staining, respectively. Kidney functions were evaluated by detecting urea nitrogen and creatinine levels in rat urine and blood. Urinary KIM?1 levels were measured using an enzyme?linked immunosorbent assay, and the protein expression levels of KIM?1, ??smooth muscle actin (??SMA) and vimentin in kidney tissues were detected using immunohistochemical assays. In order to measure KIM?1 levels, colloidal gold immunochromatographic strips were developed based on the colloidal gold immunochromatographic assay. The results indicated that KIM?1 levels were significantly higher in the UUO group when compared with the Sham group. KIM?1 levels in the urine and kidney tissues exhibited a time?dependent increase, together with increasing obstructive AKI in the UUO group. In addition, KIM?1 levels were demonstrated to be a more sensitive biomarker of early obstructive AKI, when compared with ??SMA and vimentin. A colloidal gold?based immunochromatographic strip was developed, whereby the detection of urinary KIM?1 could be completed within 5?10 min. In conclusion, results of the present study demonstrated that urinary KIM?1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM?1. |Acute Kidney Injury/*blood/diagnosis/*etiology [MESH] |Animals [MESH] |Biomarkers [MESH] |Biopsy [MESH] |Cell Adhesion Molecules/*urine [MESH] |Disease Models, Animal [MESH] |Early Diagnosis [MESH] |Female [MESH] |Immunohistochemistry [MESH] |Kidney Function Tests [MESH] |Male [MESH] |Rats [MESH]Urinary kidney injury molecule?1 as an early diagnostic biomarker of o(epmc).pdf DeepDyve Pubget Overpricing