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10.1080/15476286.2016.1189071 http://scihub22266oqcxt.onion/10.1080/15476286.2016.1189071 C5367251!5367251!27211514     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       RNA+Biol 2017 ; 14 (3): 281-6 Nephropedia Template TP {{tp|p=27211514|t=2017. Histone availability as a strategy to control gene expression |pdf=|usr=}}{{27211514}} gab.com Text Histone availability as a strategy to control gene expression JO: RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=27211514 #FOAvip Histone proteins are main structural components of the chromatin and major determinants of gene regulation. Expression of canonical histone genes is strictly controlled during the cell cycle in order to couple DNA replication with histone deposition. Indeed, reductions in the levels of canonical histones or defects in chromatin assembly cause genetic instability. Early data from yeast demonstrated that severe histone depletion also causes strong gene expression changes. We have recently reported that a moderated depletion of canonical histones in human cells leads to an open chromatin configuration, which in turn increases RNA polymerase II elongation rates and causes pre-mRNA splicing defects. Interestingly, some of the observed defects accompany the scheduled histone depletion that is associated with several senescence and aging processes. Thus, our comparison of induced and naturally-occurring histone depletion processes suggests that a programmed reduction of the level of canonical histones might be a strategy to control gene expression during specific physiological processes. Twit Text FOAVip Histone availability as a strategy to control gene expression ????RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=27211514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27211514 #FOAvip English Wikipedia <ref>{{Cite pmid|27211514}}</ref> Histone availability as a strategy to control gene expression #MMPMID27211514 Prado F; Jimeno-González S; Reyes JC RNA Biol 2017[]; 14 (3): 281-6 PMID27211514show ga Histone proteins are main structural components of the chromatin and major determinants of gene regulation. Expression of canonical histone genes is strictly controlled during the cell cycle in order to couple DNA replication with histone deposition. Indeed, reductions in the levels of canonical histones or defects in chromatin assembly cause genetic instability. Early data from yeast demonstrated that severe histone depletion also causes strong gene expression changes. We have recently reported that a moderated depletion of canonical histones in human cells leads to an open chromatin configuration, which in turn increases RNA polymerase II elongation rates and causes pre-mRNA splicing defects. Interestingly, some of the observed defects accompany the scheduled histone depletion that is associated with several senescence and aging processes. Thus, our comparison of induced and naturally-occurring histone depletion processes suggests that a programmed reduction of the level of canonical histones might be a strategy to control gene expression during specific physiological processes. äHistone availability as a strategy to control gene expression (epmc).pdf DeepDyve Pubget Overpricing