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Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 World+J+Methodol 2017 ; 7 (1): 9-15 Nephropedia Template TP
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Chromogranin A as a valid marker in oncology: Clinical application or false hopes? #MMPMID28396845
Gkolfinopoulos S; Tsapakidis K; Papadimitriou K; Papamichael D; Kountourakis P
World J Methodol 2017[Mar]; 7 (1): 9-15 PMID28396845show ga
Chromogranin A, due to its primary expression throughout the neuroendocrine system, is a widely accepted biomarker for the assessment of neuro-endocrine tumors. It has been traditionally used in the management of patients with tumors of gastro-enteropancreatic origin. Lately, it has also been implicated in various conditions and diseases, both benign and malignant. However, the paucity of data of adequate strength, as well as its relation with common physiologic conditions and its interaction with commonly prescribed medications, limit its clinical use in only a narrow spectrum. Herein, we present a thorough review to the most frequent conditions where its levels are affected, focusing specifically on its potential use as a prognostic and predictive biomarker in oncology.