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10.1038/srep45305 http://scihub22266oqcxt.onion/10.1038/srep45305 C5366887!5366887 !28345605     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28345605 &cmd=llinks): Failed to open stream: HTTP request failed! 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Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis |pdf=|usr=}}{{28345605 }} gab.com Text Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28345605 #FOAvip Reelin is an extracellular matrix protein that is crucial for neuron migration, adhesion, and positioning. We examined the expression of Reelin in a large cohort of multiple myeloma patients recorded in Gene Expression Omnibus (GEO) database and used over-expression and siRNA knockdown of Reelin to investigate the role of Reelin in myeloma cell growth. We find that Reelin expression is negatively associated with myeloma prognosis. Reelin promotes myeloma cell proliferation in vitro as well as in vivo. The Warburg effect, evidenced by increased glucose uptake and lactate production, is also enhanced in Reelin-expressing cells. The activation of FAK/Syk/Akt/mTOR and STAT3 pathways contributes to Reelin-induced cancer cell growth and metabolic reprogramming. Our findings further reveal that activated Akt and STAT3 pathways induce the upregulation of HIF1? and its downstream targets (LDHA and PDK1), leading to increased glycolysis in myeloma cells. Together, our results demonstrate the critical contributions of Reelin to myeloma growth and metabolism. It presents an opportunity for myeloma therapeutic intervention by inhibiting Reelin and its signaling pathways. Twit Text FOAVip Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28345605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28345605 #FOAvip English Wikipedia <ref>{{Cite pmid|28345605 }}</ref> Extracellular matrix protein Reelin promotes myeloma progression by facilitating tumor cell proliferation and glycolysis #MMPMID28345605 Qin X ; Lin L ; Cao L ; Zhang X ; Song X ; Hao J ; Zhang Y ; Wei R ; Huang X ; Lu J ; Ge Q Sci Rep 2017[Mar]; 7 (ä): 45305 PMID28345605 show ga Reelin is an extracellular matrix protein that is crucial for neuron migration, adhesion, and positioning. We examined the expression of Reelin in a large cohort of multiple myeloma patients recorded in Gene Expression Omnibus (GEO) database and used over-expression and siRNA knockdown of Reelin to investigate the role of Reelin in myeloma cell growth. We find that Reelin expression is negatively associated with myeloma prognosis. Reelin promotes myeloma cell proliferation in vitro as well as in vivo. The Warburg effect, evidenced by increased glucose uptake and lactate production, is also enhanced in Reelin-expressing cells. The activation of FAK/Syk/Akt/mTOR and STAT3 pathways contributes to Reelin-induced cancer cell growth and metabolic reprogramming. Our findings further reveal that activated Akt and STAT3 pathways induce the upregulation of HIF1? and its downstream targets (LDHA and PDK1), leading to increased glycolysis in myeloma cells. Together, our results demonstrate the critical contributions of Reelin to myeloma growth and metabolism. It presents an opportunity for myeloma therapeutic intervention by inhibiting Reelin and its signaling pathways. |Animals [MESH] |Cell Adhesion Molecules, Neuronal/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Movement/physiology [MESH] |Cell Proliferation/*physiology [MESH] |Extracellular Matrix Proteins/*metabolism [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic/physiology [MESH] |Glucose/metabolism [MESH] |Glycolysis/*physiology [MESH] |Humans [MESH] |Lactic Acid/metabolism [MESH] |Mice [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Multiple Myeloma/*metabolism/*pathology [MESH] |Nerve Tissue Proteins/*metabolism [MESH] |Prognosis [MESH] |RNA, Small Interfering/metabolism [MESH] |Reelin Protein [MESH] |Serine Endopeptidases/*metabolism [MESH] |Signal Transduction/physiology [MESH]Extracellular matrix protein Reelin promotes myeloma progression by fa(epmc).pdf DeepDyve Pubget Overpricing