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10.3389/fimmu.2017.00368

http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00368
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C5366881!5366881!28396673
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suck abstract from ncbi


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pmid28396673      Front+Immunol 2017 ; 8 (ä): ä
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  • Natural Killer Group 2, Member D/NKG2D Ligands in Hematopoietic Cell Transplantation #MMPMID28396673
  • Carapito R; Aouadi I; Ilias W; Bahram S
  • Front Immunol 2017[]; 8 (ä): ä PMID28396673show ga
  • Natural killer group 2, member D (NKG2D) is an invariant activatory receptor present on subsets of natural killer and T lymphocytes. It stimulates the cytolytic effector response upon engagement of its various stress-induced ligands NKG2D ligands (NKG2DL). Malignant transformation and conditioning treatment prior to hematopoietic cell transplantation (HCT) are stress factors leading to the activation of the NKG2D/NKG2DL signaling in clinical settings. In the context of HCT, NKG2D-bearing cells can kill both tumor and healthy cells expressing NKG2DL. The NKG2D/NKG2DL engagement has therefore a key role in the regulation of one of the most salient issues in allogeneic HCT, i.e., maintaining a balance between graft-vs.-leukemia effect and graft-vs.-host disease. The present review summarizes the current state of our knowledge pertaining to the role of the NKG2D and NKG2DL in HCT.
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