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10.1016/j.molimm.2016.11.003 http://scihub22266oqcxt.onion/10.1016/j.molimm.2016.11.003 C5366276!5366276!27914690     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Immunol 2017 ; 84 (ä): 26-33 Nephropedia Template TP {{tp|p=27914690|t=2017. C1q as an autocrine and paracrine regulator of cellular functions |pdf=|usr=}}{{27914690}} gab.com Text C1q as an autocrine and paracrine regulator of cellular functions JO: Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27914690 #FOAvip Most of the complement proteins in circulation are, by and large, synthesized in the liver. However data accumulated over the past several decades provide incontrovertible evidence that some if not most of the individual complement proteins are also synthesized extrahepatically by activated as well as non-activated cells. The question that is finally being addressed by various investigators is: are the locally synthesized proteins solely responsible for the myriad of biological functions in situ without the contribution of systemic complement? The answer is probably ?yes?. Among the proteins that are synthesized locally, C1q takes center stage for several reasons. First, it is synthesized predominantly by potent antigen presenting cells such as monocytes, macrophages and dendritic cells (DCs), which by itself is a clue that it plays an important role in antigen presentation and/or DC maturation. Second, it is transiently anchored on the cell surface via a transmembrane domain located in its A chain before it is cleaved off and released into the pericellular milieu. The membrane-associated C1q in turn, is able to sense danger patterns via its versatile antigen-capturing globular head domains. More importantly, locally synthesized C1q has been shown to induce a plethora of biological functions through the induction of immunomodulatory molecules by an autocrine- or paracrine-mediated signaling in a manner that mimics those of TNF?. These include recognition of pathogen- and danger-associated molecular patterns, phagocytosis, angiogenesis, apoptosis and induction of cytokines or chemokines that are important in modulating the inflammatory response. The functional convergence between C1q and TNF? in turn is attributed to their shared genetic ancestry. In this paper, we will infer to the aforementioned ?local-synthesis-for-local function? paradigm using as an example, the role played by locally synthesized C1q in autoimmunity in general and in systemic lupus erythematosus in particular. Twit Text FOAVip C1q as an autocrine and paracrine regulator of cellular functions ????Mol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27914690 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27914690 #FOAvip English Wikipedia <ref>{{Cite pmid|27914690}}</ref> C1q as an autocrine and paracrine regulator of cellular functions #MMPMID27914690 Ghebrehiwet B; Hosszu KH; Peerschke EI Mol Immunol 2017[Apr]; 84 (ä): 26-33 PMID27914690show ga Most of the complement proteins in circulation are, by and large, synthesized in the liver. However data accumulated over the past several decades provide incontrovertible evidence that some if not most of the individual complement proteins are also synthesized extrahepatically by activated as well as non-activated cells. The question that is finally being addressed by various investigators is: are the locally synthesized proteins solely responsible for the myriad of biological functions in situ without the contribution of systemic complement? The answer is probably ?yes?. Among the proteins that are synthesized locally, C1q takes center stage for several reasons. First, it is synthesized predominantly by potent antigen presenting cells such as monocytes, macrophages and dendritic cells (DCs), which by itself is a clue that it plays an important role in antigen presentation and/or DC maturation. Second, it is transiently anchored on the cell surface via a transmembrane domain located in its A chain before it is cleaved off and released into the pericellular milieu. The membrane-associated C1q in turn, is able to sense danger patterns via its versatile antigen-capturing globular head domains. More importantly, locally synthesized C1q has been shown to induce a plethora of biological functions through the induction of immunomodulatory molecules by an autocrine- or paracrine-mediated signaling in a manner that mimics those of TNF?. These include recognition of pathogen- and danger-associated molecular patterns, phagocytosis, angiogenesis, apoptosis and induction of cytokines or chemokines that are important in modulating the inflammatory response. The functional convergence between C1q and TNF? in turn is attributed to their shared genetic ancestry. In this paper, we will infer to the aforementioned ?local-synthesis-for-local function? paradigm using as an example, the role played by locally synthesized C1q in autoimmunity in general and in systemic lupus erythematosus in particular. äC1q as an autocrine and paracrine regulator of cellular functions (epmc).pdf DeepDyve Pubget Overpricing