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2017 ; 6
(ä): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Advances in understanding the renin-angiotensin-aldosterone system (RAAS) in
blood pressure control and recent pivotal trials of RAAS blockade in heart
failure and diabetic nephropathy
#MMPMID28413612
Ghazi L
; Drawz P
F1000Res
2017[]; 6
(ä): ä PMID28413612
show ga
The renin-angiotensin-aldosterone system (RAAS) plays a fundamental role in the
physiology of blood pressure control and the pathophysiology of hypertension
(HTN) with effects on vascular tone, sodium retention, oxidative stress,
fibrosis, sympathetic tone, and inflammation. Fortunately, RAAS blocking agents
have been available to treat HTN since the 1970s and newer medications are being
developed. In this review, we will (1) examine new anti-hypertensive medications
affecting the RAAS, (2) evaluate recent studies that help provide a better
understanding of which patients may be more likely to benefit from RAAS blockade,
and (3) review three recent pivotal randomized trials that involve newer RAAS
blocking agents and inform clinical practice.