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10.20892/j.issn.2095-3941.2016.0086 http://scihub22266oqcxt.onion/10.20892/j.issn.2095-3941.2016.0086 C5365179!5365179!28443208     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Biol+Med 2017 ; 14 (1): 90-9 Nephropedia Template TP {{tp|p=28443208|t=2017. Roles of Rap1 signaling in tumor cell migration and invasion |pdf=|usr=}}{{28443208}} gab.com Text Roles of Rap1 signaling in tumor cell migration and invasion JO: Cancer Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=28443208 #FOAvip Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate (GTP) or guanosine diphosphate (GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression. Twit Text FOAVip Roles of Rap1 signaling in tumor cell migration and invasion ????Cancer Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=28443208 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28443208 #FOAvip English Wikipedia <ref>{{Cite pmid|28443208}}</ref> Roles of Rap1 signaling in tumor cell migration and invasion #MMPMID28443208 Zhang YL; Wang RC; Cheng K; Ring BZ; Su L Cancer Biol Med 2017[Feb]; 14 (1): 90-9 PMID28443208show ga Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate (GTP) or guanosine diphosphate (GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression. äRoles of Rap1 signaling in tumor cell migration and invasion (epmc).pdf DeepDyve Pubget Overpricing