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10.1371/journal.pone.0174585 http://scihub22266oqcxt.onion/10.1371/journal.pone.0174585 C5365120!5365120 !28339495     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28339495 &cmd=llinks): Failed to open stream: HTTP request failed! 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MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren s syndrome |pdf=|usr=}}{{28339495 }} gab.com Text MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren s syndrome JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28339495 #FOAvip The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological disturbances in autoimmune diseases. The aim of our study was to examine the changes in miRNA expression profiles in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Eight SLE patients, 8 pSS patients and 7 healthy subjects were enrolled in the investigation. MiRNAs were isolated from peripheral blood mononuclear cells, and expression patterns were determined with Illumina next-generation sequencing technology. Since the immunopathogenesis of pSS and SLE encompasses pronounced B cell hyperactivity along with specific autoantibody production, we paid a special attention on the association between miRNA expression levels and altered peripheral B cell distribution. In SLE patients 135, while in pSS patients 26 miRNAs showed altered expression. Interestingly, the 25 miRNAs including miR-146a, miR-16 and miR-21, which were over-expressed in pSS patients, were found to be elevated in SLE group, as well. On the contrary, we observed the down-regulation of miR-150-5p, which is a novel and unique finding in pSS. Levels of several miRNAs over-expressed in SLE, were not changed in pSS, such as miR-148a-3p, miR-152, miR-155, miR-223, miR-224, miR-326 and miR-342. Expression levels of miR-223-5p, miR-150-5p, miR-155-5p and miR-342-3p, which miRNAs are potentially linked to B cell functions, showed associations with the B cell proportions within peripheral blood mononuclear cells. The observed differences in miRNA expression profiles and the better understanding of immune regulatory mechanisms of miRNAs may help to elucidate the pathogenesis of SLE and pSS. Twit Text FOAVip MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren s syndrome ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=28339495 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28339495 #FOAvip English Wikipedia <ref>{{Cite pmid|28339495 }}</ref> MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjögren s syndrome #MMPMID28339495 Chen JQ ; Papp G ; Póliska S ; Szabó K ; Tarr T ; Bálint BL ; Szodoray P ; Zeher M PLoS One 2017[]; 12 (3 ): e0174585 PMID28339495 show ga The discovery of microRNAs (miRNAs) and their critical role in genetic control opened new avenues in understanding of various biological processes including immune cell lineage commitment, differentiation, proliferation and apoptosis. However, a given miRNA may have hundreds of different mRNA targets and a target might be regulated by multiple miRNAs, thus the characterisation of dysregulated miRNA expression profiles could give a better insight into the development of immunological disturbances in autoimmune diseases. The aim of our study was to examine the changes in miRNA expression profiles in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Eight SLE patients, 8 pSS patients and 7 healthy subjects were enrolled in the investigation. MiRNAs were isolated from peripheral blood mononuclear cells, and expression patterns were determined with Illumina next-generation sequencing technology. Since the immunopathogenesis of pSS and SLE encompasses pronounced B cell hyperactivity along with specific autoantibody production, we paid a special attention on the association between miRNA expression levels and altered peripheral B cell distribution. In SLE patients 135, while in pSS patients 26 miRNAs showed altered expression. Interestingly, the 25 miRNAs including miR-146a, miR-16 and miR-21, which were over-expressed in pSS patients, were found to be elevated in SLE group, as well. On the contrary, we observed the down-regulation of miR-150-5p, which is a novel and unique finding in pSS. Levels of several miRNAs over-expressed in SLE, were not changed in pSS, such as miR-148a-3p, miR-152, miR-155, miR-223, miR-224, miR-326 and miR-342. Expression levels of miR-223-5p, miR-150-5p, miR-155-5p and miR-342-3p, which miRNAs are potentially linked to B cell functions, showed associations with the B cell proportions within peripheral blood mononuclear cells. The observed differences in miRNA expression profiles and the better understanding of immune regulatory mechanisms of miRNAs may help to elucidate the pathogenesis of SLE and pSS. |*Gene Expression Regulation [MESH] |Adult [MESH] |Aged [MESH] |B-Lymphocytes/metabolism [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Humans [MESH] |Leukocytes, Mononuclear/metabolism [MESH] |Lupus Erythematosus, Systemic/*genetics/metabolism [MESH] |MicroRNAs/*genetics/metabolism [MESH] |Middle Aged [MESH]MicroRNA expression profiles identify disease-specific alterations in (epmc).pdf DeepDyve Pubget Overpricing