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10.3892/mmr.2017.6208 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6208 C5364985!5364985 !28260014     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28260014 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2017 ; 15 (4 ): 1702-1712 Nephropedia Template TP {{tp|p=28260014 |t=2017. Baicalin ameliorates renal fibrosis via inhibition of transforming growth factor ?1 production and downstream signal transduction |pdf=|usr=}}{{28260014 }} gab.com Text Baicalin ameliorates renal fibrosis via inhibition of transforming growth factor 1 production and downstream signal transduction JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28260014 #FOAvip Previous studies have demonstrated the potential antifibrotic effects of baicalin in vitro, via examination of 21 compounds isolated from plants. However, its biological activity and underlying mechanisms of action in vivo remain to be elucidated. The present study aimed to evaluate the effect of baicalin on renal fibrosis in vivo, and the potential signaling pathways involved. A unilateral ureteral obstruction (UUO)?induced renal fibrosis model was established using Sprague?Dawley rats. Baicalin was administrated intraperitoneally every 2 days for 10 days. The degree of renal damage and fibrosis was investigated by histological assessment, and detection of fibronectin and collagen I mRNA expression levels. Epithelial?mesenchymal transition (EMT) markers, transforming growth factor-?1 (TGF-?1) levels and downstream phosphorylation of mothers against decapentaplegic 2/3 (Smad2/3) were examined in vivo and in an NRK?52E rat renal tubular cell line in vitro. Baicalin was demonstrated to markedly ameliorate renal fibrosis and suppress EMT, as evidenced by reduced interstitial collagen accumulation, decreased fibronectin and collagen I mRNA expression levels, upregulation of N? and E?cadherin expression levels, and downregulation of ??smooth muscle actin and vimentin expression. Furthermore, baicalin decreased TGF??1 expression levels in serum and kidney tissue following UUO, and suppressed Smad2/3 phosphorylation in rat kidney tissue. In vitro studies identified that baicalin may inhibit the phosphorylation of Smad2/3 under the same TGF??1 concentration. In conclusion, baicalin may protect against renal fibrosis, potentially via inhibition of TGF??1 production and its downstream signal transduction. Twit Text FOAVip Baicalin ameliorates renal fibrosis via inhibition of transforming growth factor 1 production and downstream signal transduction ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28260014 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28260014 #FOAvip English Wikipedia <ref>{{Cite pmid|28260014 }}</ref> Baicalin ameliorates renal fibrosis via inhibition of transforming growth factor ?1 production and downstream signal transduction #MMPMID28260014 Zheng L ; Zhang C ; Li L ; Hu C ; Hu M ; Sidikejiang N ; Wang X ; Lin M ; Rong R Mol Med Rep 2017[Apr]; 15 (4 ): 1702-1712 PMID28260014 show ga Previous studies have demonstrated the potential antifibrotic effects of baicalin in vitro, via examination of 21 compounds isolated from plants. However, its biological activity and underlying mechanisms of action in vivo remain to be elucidated. The present study aimed to evaluate the effect of baicalin on renal fibrosis in vivo, and the potential signaling pathways involved. A unilateral ureteral obstruction (UUO)?induced renal fibrosis model was established using Sprague?Dawley rats. Baicalin was administrated intraperitoneally every 2 days for 10 days. The degree of renal damage and fibrosis was investigated by histological assessment, and detection of fibronectin and collagen I mRNA expression levels. Epithelial?mesenchymal transition (EMT) markers, transforming growth factor-?1 (TGF-?1) levels and downstream phosphorylation of mothers against decapentaplegic 2/3 (Smad2/3) were examined in vivo and in an NRK?52E rat renal tubular cell line in vitro. Baicalin was demonstrated to markedly ameliorate renal fibrosis and suppress EMT, as evidenced by reduced interstitial collagen accumulation, decreased fibronectin and collagen I mRNA expression levels, upregulation of N? and E?cadherin expression levels, and downregulation of ??smooth muscle actin and vimentin expression. Furthermore, baicalin decreased TGF??1 expression levels in serum and kidney tissue following UUO, and suppressed Smad2/3 phosphorylation in rat kidney tissue. In vitro studies identified that baicalin may inhibit the phosphorylation of Smad2/3 under the same TGF??1 concentration. In conclusion, baicalin may protect against renal fibrosis, potentially via inhibition of TGF??1 production and its downstream signal transduction. |Animals [MESH] |Disease Models, Animal [MESH] |Epithelial-Mesenchymal Transition/drug effects [MESH] |Fibrosis [MESH] |Flavonoids/*pharmacology/*therapeutic use [MESH] |Immunohistochemistry [MESH] |Kidney Diseases/*drug therapy/metabolism/*pathology [MESH] |Kidney/drug effects/metabolism/pathology [MESH] |Male [MESH] |Models, Biological [MESH] |Phosphorylation/drug effects [MESH] |Rats, Sprague-Dawley [MESH] |Signal Transduction/*drug effects [MESH] |Smad Proteins/metabolism [MESH] |Transforming Growth Factor beta1/*biosynthesis [MESH]Baicalin ameliorates renal fibrosis via inhibition of transforming gro(epmc).pdf DeepDyve Pubget Overpricing