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10.3892/mmr.2017.6236 http://scihub22266oqcxt.onion/10.3892/mmr.2017.6236 C5364886!5364886 !28259939     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28259939 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Med+Rep 2017 ; 15 (4 ): 2154-2162 Nephropedia Template TP {{tp|p=28259939 |t=2017. The role of ZFP580, a novel zinc finger protein, in TGF-mediated cytoprotection against chemical hypoxia?induced apoptosis in H9c2 cardiac myocytes |pdf=|usr=}}{{28259939 }} gab.com Text The role of ZFP580, a novel zinc finger protein, in TGF-mediated cytoprotection against chemical hypoxia induced apoptosis in H9c2 cardiac myocytes JO: Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28259939 #FOAvip Zing finger protein 580 (ZFP580) is a novel Cys2-His2 zinc-finger transcription factor that has an anti-apoptotic role in myocardial cells. It is involved in the endothelial transforming growth factor??1 (TGF??1) signal transduction pathway as a mothers against decapentaplegic homolog (Smad)2 binding partner. The aim of the present study was to determine the involvement of ZFP580 in TGF??1?mediated cytoprotection against chemical hypoxia?induced apoptosis, using H9c2 cardiac myocytes. Hypoxia was chemically induced in H9c2 myocardial cells by exposure to cobalt chloride (CoCl2). In response to hypoxia, cell viability was decreased, whereas the expression levels of hypoxia inducible factor-1? and ZFP580 were increased. Pretreatment with TGF??1 attenuated CoCl2?induced cell apoptosis and upregulated ZFP580 protein expression; however, these effects could be suppressed by SB431542, an inhibitor of TGF?? type I receptor and Smad2/3 phosphorylation. Furthermore, suppression of ZFP580 expression by RNA interference reduced the anti?apoptotic effects of TGF??1 and thus increased CoCl2?induced apoptosis. B?cell lymphoma (Bcl)?2?associated X protein/Bcl?2 ratio, reactive oxygen species generation and caspase?3 activation were also increased following ZFP580 inactivation. In conclusion, these results indicate that ZFP580 is a component of the TGF-?1/Smad signaling pathway, and is involved in the protective effects of TGF??1 against chemical hypoxia?induced cell apoptosis, through inhibition of the mitochondrial apoptotic pathway. Twit Text FOAVip The role of ZFP580, a novel zinc finger protein, in TGF-mediated cytoprotection against chemical hypoxia induced apoptosis in H9c2 cardiac myocytes ????Mol Med Rep http://www.kidney.de/pget.php?&tw=1&pmid=28259939 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28259939 #FOAvip English Wikipedia <ref>{{Cite pmid|28259939 }}</ref> The role of ZFP580, a novel zinc finger protein, in TGF-mediated cytoprotection against chemical hypoxia?induced apoptosis in H9c2 cardiac myocytes #MMPMID28259939 Mao SY ; Meng XY ; Xu ZW ; Zhang WC ; Jin XH ; Chen X ; Zhou X ; Li YM ; Xu RC Mol Med Rep 2017[Apr]; 15 (4 ): 2154-2162 PMID28259939 show ga Zing finger protein 580 (ZFP580) is a novel Cys2-His2 zinc-finger transcription factor that has an anti-apoptotic role in myocardial cells. It is involved in the endothelial transforming growth factor??1 (TGF??1) signal transduction pathway as a mothers against decapentaplegic homolog (Smad)2 binding partner. The aim of the present study was to determine the involvement of ZFP580 in TGF??1?mediated cytoprotection against chemical hypoxia?induced apoptosis, using H9c2 cardiac myocytes. Hypoxia was chemically induced in H9c2 myocardial cells by exposure to cobalt chloride (CoCl2). In response to hypoxia, cell viability was decreased, whereas the expression levels of hypoxia inducible factor-1? and ZFP580 were increased. Pretreatment with TGF??1 attenuated CoCl2?induced cell apoptosis and upregulated ZFP580 protein expression; however, these effects could be suppressed by SB431542, an inhibitor of TGF?? type I receptor and Smad2/3 phosphorylation. Furthermore, suppression of ZFP580 expression by RNA interference reduced the anti?apoptotic effects of TGF??1 and thus increased CoCl2?induced apoptosis. B?cell lymphoma (Bcl)?2?associated X protein/Bcl?2 ratio, reactive oxygen species generation and caspase?3 activation were also increased following ZFP580 inactivation. In conclusion, these results indicate that ZFP580 is a component of the TGF-?1/Smad signaling pathway, and is involved in the protective effects of TGF??1 against chemical hypoxia?induced cell apoptosis, through inhibition of the mitochondrial apoptotic pathway. |Animals [MESH] |Apoptosis/*drug effects [MESH] |Cell Hypoxia/*drug effects [MESH] |Cell Line [MESH] |Cell Survival/drug effects [MESH] |Cobalt/*toxicity [MESH] |Cytoprotection [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/metabolism [MESH] |Myocytes, Cardiac/*cytology/*drug effects/metabolism [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Rats [MESH] |Reactive Oxygen Species/metabolism [MESH] |Receptor, Transforming Growth Factor-beta Type I [MESH] |Receptors, Transforming Growth Factor beta/metabolism [MESH] |Smad2 Protein/metabolism [MESH] |Smad3 Protein/metabolism [MESH] |Transcription Factors/*metabolism [MESH]The role of ZFP580, a novel zinc finger protein, in TGF-mediated cytop(epmc).pdf DeepDyve Pubget Overpricing