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10.1186/s13072-017-0122-8 http://scihub22266oqcxt.onion/10.1186/s13072-017-0122-8 C5364561!5364561!28344658     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Epigenetics+Chromatin 2017 ; 10 (ä): ä Nephropedia Template TP {{tp|p=28344658|t=2017. Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes |pdf=|usr=}}{{28344658}} gab.com Text Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes JO: Epigenetics Chromatin http://www.kidney.de/pget.php?&tw=1&pmid=28344658 #FOAvip Background: Despite recent studies on the role of ubiquitin-related SUMO modifier in cell fate decisions, our understanding on precise molecular mechanisms of these processes is limited. Previously, we established that the SUMO isopeptidase SENP3 regulates chromatin assembly of the MLL1/2 histone methyltransferase complex at distinct HOX genes, including the osteogenic master regulator DLX3. A comprehensive mechanism that regulates SENP3 transcriptional function was not understood. Results: Here, we identified flightless-I homolog (FLII), a member of the gelsolin family of actin-remodeling proteins, as a novel regulator of SENP3. We demonstrate that FLII is associated with SENP3 and the MLL1/2 complex. We further show that FLII determines SENP3 recruitment and MLL1/2 complex assembly on the DLX3 gene. Consequently, FLII is indispensible for H3K4 methylation and proper loading of active RNA polymerase II at this gene locus. Most importantly, FLII-mediated SENP3 regulation governs osteogenic differentiation of human mesenchymal stem cells. Conclusion: Altogether, these data reveal a crucial functional interconnection of FLII with the sumoylation machinery that converges on epigenetic regulation and cell fate determination. Electronic supplementary material: The online version of this article (doi:10.1186/s13072-017-0122-8) contains supplementary material, which is available to authorized users. Twit Text FOAVip Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes ????Epigenetics Chromatin http://www.kidney.de/pget.php?&tw=1&pmid=28344658 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28344658 #FOAvip English Wikipedia <ref>{{Cite pmid|28344658}}</ref> Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes #MMPMID28344658 Nayak A; Reck A; Morsczeck C; Müller S Epigenetics Chromatin 2017[]; 10 (ä): ä PMID28344658show ga Background: Despite recent studies on the role of ubiquitin-related SUMO modifier in cell fate decisions, our understanding on precise molecular mechanisms of these processes is limited. Previously, we established that the SUMO isopeptidase SENP3 regulates chromatin assembly of the MLL1/2 histone methyltransferase complex at distinct HOX genes, including the osteogenic master regulator DLX3. A comprehensive mechanism that regulates SENP3 transcriptional function was not understood. Results: Here, we identified flightless-I homolog (FLII), a member of the gelsolin family of actin-remodeling proteins, as a novel regulator of SENP3. We demonstrate that FLII is associated with SENP3 and the MLL1/2 complex. We further show that FLII determines SENP3 recruitment and MLL1/2 complex assembly on the DLX3 gene. Consequently, FLII is indispensible for H3K4 methylation and proper loading of active RNA polymerase II at this gene locus. Most importantly, FLII-mediated SENP3 regulation governs osteogenic differentiation of human mesenchymal stem cells. Conclusion: Altogether, these data reveal a crucial functional interconnection of FLII with the sumoylation machinery that converges on epigenetic regulation and cell fate determination. Electronic supplementary material: The online version of this article (doi:10.1186/s13072-017-0122-8) contains supplementary material, which is available to authorized users. äFlightless-I governs cell fate by recruiting the SUMO isopeptidase SEN(epmc).pdf DeepDyve Pubget Overpricing