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10.1016/bs.acr.2016.05.004 http://scihub22266oqcxt.onion/10.1016/bs.acr.2016.05.004 C5364524!5364524!27613132     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Cancer+Res 2016 ; 132 (ä): 139-63 Nephropedia Template TP {{tp|p=27613132|t=2016. Immune regulation of the metastatic process: implications for therapy |pdf=|usr=}}{{27613132}} gab.com Text Immune regulation of the metastatic process: implications for therapy JO: Adv Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27613132 #FOAvip Metastatic disease is the major cause of fatalities in cancer patients, but few therapies are designed to target the metastatic process. Cancer cells must perform a number of steps to successfully establish metastatic foci, including local invasion, intravasation, survival, extravasation, and growth in ectopic tissue. Due to the non-random distribution of metastasis, it has long been recognized that the tissue microenvironment must be an important determinant of colonization. More recently it has been established in animal models that immune cells regulate the metastatic process, including a dominant role for monocytes and macrophages, and emerging roles for neutrophils and various lymphocyte populations. While most research has focused on the early dissemination process, patients usually present clinically with disseminated, if not macroscopic, disease. Identifying pathways by which immune cells regulate growth and therapeutic resistance within metastatic sites is therefore key to the development of pharmacological agents that will significantly extend patient survival. Twit Text FOAVip Immune regulation of the metastatic process: implications for therapy ????Adv Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=27613132 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27613132 #FOAvip English Wikipedia <ref>{{Cite pmid|27613132}}</ref> Immune regulation of the metastatic process: implications for therapy #MMPMID27613132 de Mingo Pulido A; Ruffell B Adv Cancer Res 2016[]; 132 (ä): 139-63 PMID27613132show ga Metastatic disease is the major cause of fatalities in cancer patients, but few therapies are designed to target the metastatic process. Cancer cells must perform a number of steps to successfully establish metastatic foci, including local invasion, intravasation, survival, extravasation, and growth in ectopic tissue. Due to the non-random distribution of metastasis, it has long been recognized that the tissue microenvironment must be an important determinant of colonization. More recently it has been established in animal models that immune cells regulate the metastatic process, including a dominant role for monocytes and macrophages, and emerging roles for neutrophils and various lymphocyte populations. While most research has focused on the early dissemination process, patients usually present clinically with disseminated, if not macroscopic, disease. Identifying pathways by which immune cells regulate growth and therapeutic resistance within metastatic sites is therefore key to the development of pharmacological agents that will significantly extend patient survival. äImmune regulation of the metastatic process: implications for therapy (epmc).pdf DeepDyve Pubget Overpricing