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10.1038/srep42928 http://scihub22266oqcxt.onion/10.1038/srep42928 C5364507!5364507 !28338004     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28338004 &cmd=llinks): Failed to open stream: HTTP request failed! 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TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport |pdf=|usr=}}{{28338004 }} gab.com Text TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28338004 #FOAvip The up-regulation of thioredoxin reductase-1 (TrxR1) is detected in more than half of gliomas, which is significantly associated with increased malignancy grade and recurrence rate. The biological functions of NADPH-dependent TrxR1 are mainly associated with reduced thioredoxin-1 (Trx1) which plays critical roles in cellular redox signaling and tumour radio-resistance. Our previous work has proved that TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown could notably radiosensitize glioma cells. However, whether TrxR1-overexpressing glioma cells could be re-radiosensitized by TIGAR silence is still far from clear. In the present study, TrxR1 was stably over-expressed in U-87MG and T98G glioma cells. Both in vitro and in vivo data demonstrated that the radiosensitivity of glioma cells was considerably diminished by TrxR1 overexpression. TIGAR abrogation was able to radiosensitize TrxR1-overexpressing gliomas by inhibiting IR-induced Trx1 nuclear transport. Post-radiotherapy, TIGAR low-expression predicted significant longer survival time for animals suffering from TrxR1-overexpessing xenografts, which suggested that TIGAR abrogation might be a promising strategy for radiosensitizing TrxR1-overexpressing glial tumours. Twit Text FOAVip TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28338004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28338004 #FOAvip English Wikipedia <ref>{{Cite pmid|28338004 }}</ref> TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport #MMPMID28338004 Zhang Y ; Chen F ; Tai G ; Wang J ; Shang J ; Zhang B ; Wang P ; Huang B ; Du J ; Yu J ; Zhang H ; Liu F Sci Rep 2017[Mar]; 7 (ä): 42928 PMID28338004 show ga The up-regulation of thioredoxin reductase-1 (TrxR1) is detected in more than half of gliomas, which is significantly associated with increased malignancy grade and recurrence rate. The biological functions of NADPH-dependent TrxR1 are mainly associated with reduced thioredoxin-1 (Trx1) which plays critical roles in cellular redox signaling and tumour radio-resistance. Our previous work has proved that TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown could notably radiosensitize glioma cells. However, whether TrxR1-overexpressing glioma cells could be re-radiosensitized by TIGAR silence is still far from clear. In the present study, TrxR1 was stably over-expressed in U-87MG and T98G glioma cells. Both in vitro and in vivo data demonstrated that the radiosensitivity of glioma cells was considerably diminished by TrxR1 overexpression. TIGAR abrogation was able to radiosensitize TrxR1-overexpressing gliomas by inhibiting IR-induced Trx1 nuclear transport. Post-radiotherapy, TIGAR low-expression predicted significant longer survival time for animals suffering from TrxR1-overexpessing xenografts, which suggested that TIGAR abrogation might be a promising strategy for radiosensitizing TrxR1-overexpressing glial tumours. |Active Transport, Cell Nucleus/radiation effects [MESH] |Animals [MESH] |Apoptosis Regulatory Proteins [MESH] |Brain Neoplasms/mortality/pathology/radiotherapy [MESH] |Cell Line, Tumor [MESH] |DNA Damage/radiation effects [MESH] |Female [MESH] |Glioma/mortality/pathology/radiotherapy [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/antagonists & inhibitors/genetics/*metabolism [MESH] |Kaplan-Meier Estimate [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |NADP/metabolism [MESH] |Phosphoric Monoester Hydrolases [MESH] |RNA Interference [MESH] |RNA, Small Interfering/metabolism [MESH] |Radiation Tolerance [MESH] |Radiation, Ionizing [MESH] |Reactive Oxygen Species/metabolism [MESH]TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro a(epmc).pdf DeepDyve Pubget Overpricing