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10.1016/j.molcel.2017.02.005 http://scihub22266oqcxt.onion/10.1016/j.molcel.2017.02.005 C5364370!5364370 !28286024     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28286024 &cmd=llinks): Failed to open stream: HTTP request failed! 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ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription |pdf=|usr=}}{{28286024 }} gab.com Text ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28286024 #FOAvip We investigated the relationship among ERK signaling, histone modifications, and transcription factor activity, focusing on the ERK-regulated ternary complex factor family of SRF partner proteins. In MEFs, activation of ERK by TPA stimulation induced a common pattern of H3K9acS10ph, H4K16ac, H3K27ac, H3K9acK14ac, and H3K4me3 at hundreds of transcription start site (TSS) regions and remote regulatory sites. The magnitude of the increase in histone modification correlated well with changes in transcription. H3K9acS10ph preceded the other modifications. Most induced changes were TCF dependent, but TCF-independent TSSs exhibited the same hierarchy, indicating that it reflects gene activation per se. Studies with TCF Elk-1 mutants showed that TCF-dependent ERK-induced histone modifications required Elk-1 to be phosphorylated and competent to activate transcription. Analysis of direct TCF-SRF target genes and chromatin modifiers confirmed this and showed that H3S10ph required only Elk-1 phosphorylation. Induction of histone modifications following ERK stimulation is thus directed by transcription factor activation and transcription. Twit Text FOAVip ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=28286024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28286024 #FOAvip English Wikipedia <ref>{{Cite pmid|28286024 }}</ref> ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chromatin Modification Cascade Associated with Transcription #MMPMID28286024 Esnault C ; Gualdrini F ; Horswell S ; Kelly G ; Stewart A ; East P ; Matthews N ; Treisman R Mol Cell 2017[Mar]; 65 (6 ): 1081-1095.e5 PMID28286024 show ga We investigated the relationship among ERK signaling, histone modifications, and transcription factor activity, focusing on the ERK-regulated ternary complex factor family of SRF partner proteins. In MEFs, activation of ERK by TPA stimulation induced a common pattern of H3K9acS10ph, H4K16ac, H3K27ac, H3K9acK14ac, and H3K4me3 at hundreds of transcription start site (TSS) regions and remote regulatory sites. The magnitude of the increase in histone modification correlated well with changes in transcription. H3K9acS10ph preceded the other modifications. Most induced changes were TCF dependent, but TCF-independent TSSs exhibited the same hierarchy, indicating that it reflects gene activation per se. Studies with TCF Elk-1 mutants showed that TCF-dependent ERK-induced histone modifications required Elk-1 to be phosphorylated and competent to activate transcription. Analysis of direct TCF-SRF target genes and chromatin modifiers confirmed this and showed that H3S10ph required only Elk-1 phosphorylation. Induction of histone modifications following ERK stimulation is thus directed by transcription factor activation and transcription. |*Chromatin Assembly and Disassembly/drug effects [MESH] |*Transcription, Genetic/drug effects [MESH] |Animals [MESH] |Cell Line [MESH] |Chromatin/drug effects/*enzymology/genetics [MESH] |Early Growth Response Protein 1/genetics/metabolism [MESH] |Enzyme Activation [MESH] |Extracellular Signal-Regulated MAP Kinases/*metabolism [MESH] |Histones/*metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Mutation [MESH] |Phosphorylation [MESH] |RNA Interference [MESH] |Serum Response Factor/genetics/*metabolism [MESH] |Signal Transduction [MESH] |TCF Transcription Factors/genetics/*metabolism [MESH] |Tetradecanoylphorbol Acetate/pharmacology [MESH] |Transcription Initiation Site [MESH] |Transfection [MESH]ERK-Induced Activation of TCF Family of SRF Cofactors Initiates a Chro(epmc).pdf DeepDyve Pubget Overpricing