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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Kidney+Cancer+VHL
2017 ; 4
(1
): 16-24
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Maslinic Acid Inhibits Proliferation of Renal Cell Carcinoma Cell Lines and
Suppresses Angiogenesis of Endothelial Cells
#MMPMID28405545
Thakor P
; Song W
; Subramanian RB
; Thakkar VR
; Vesey DA
; Gobe GC
J Kidney Cancer VHL
2017[]; 4
(1
): 16-24
PMID28405545
show ga
Despite the introduction of many novel therapeutics in clinical practice,
metastatic renal cell carcinoma (RCC) remains a treatment-resistant cancer. As
red and processed meat are considered risk factors for RCC, and a vegetable-rich
diet is thought to reduce this risk, research into plant-based therapeutics may
provide valuable complementary or alternative therapeutics for the management of
RCC. Herein, we present the antiproliferative and antiangiogenic effects of
maslinic acid, which occurs naturally in edible plants, particularly in olive
fruits, and also in a variety of medicinal plants. Human RCC cell lines (ACHN,
Caki-1, and SN12K1), endothelial cells (human umbilical vein endothelial cell
line [HUVEC]), and primary cultures of kidney proximal tubular epithelial cells
(PTEC) were treated with maslinic acid. Maslinic acid was relatively less toxic
to PTEC when compared with RCC under similar experimental conditions. In RCC cell
lines, maslinic acid induced a significant reduction in proliferation,
proliferating cell nuclear antigen, and colony formation. In HUVEC, maslinic acid
induced a significant reduction in capillary tube formation in vitro and vascular
endothelial growth factor. This study provides a rationale for incorporating a
maslinic acid-rich diet either to reduce the risk of developing kidney cancer or
as an adjunct to existing antiangiogenic therapy to improve efficacy.