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2017 ; 9
(ä): 1-9
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Contrasting roles for DNA methyltransferases and histone deacetylases in
single-item and associative recognition memory
#MMPMID28367410
Scott H
; Smith AE
; Barker GR
; Uney JB
; Warburton EC
Neuroepigenetics
2017[Mar]; 9
(ä): 1-9
PMID28367410
show ga
Recognition memory enables us to judge whether we have encountered a stimulus
before and to recall associated information, including where the stimulus was
encountered. The perirhinal cortex (PRh) is required for judgment of stimulus
familiarity, while hippocampus (HPC) and medial prefrontal cortex (mPFC) are
additionally involved when spatial information associated with a stimulus needs
to be remembered. While gene expression is known to be essential for the
consolidation of long-term recognition memory, the underlying regulatory
mechanisms are not fully understood. Here we investigated the roles of two
epigenetic mechanisms, DNA methylation and histone deacetylation, in recognition
memory. Infusion of DNA methyltransferase inhibitors into PRh impaired
performance in novel object recognition and object-in-place tasks while infusions
into HPC or mPFC impaired object-in-place performance only. In contrast,
inhibition of histone deacetylases in PRh, but not mPFC, enhanced recognition
memory. These results support the emerging role of epigenetic processes in
learning and memory.