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10.2169/internalmedicine.56.7754

http://scihub22266oqcxt.onion/10.2169/internalmedicine.56.7754
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suck abstract from ncbi


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pmid28202871
      Intern+Med 2017 ; 56 (4 ): 455-459
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  • The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation #MMPMID28202871
  • Godo S ; Yoshida Y ; Fujita M ; Kudo D ; Nomura R ; Shimokawa H ; Kushimoto S
  • Intern Med 2017[]; 56 (4 ): 455-459 PMID28202871 show ga
  • Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus. Although they can cause lactic acidosis in susceptible patients with predisposing risk factors, the incidence of lactic acidosis is reported to be very low when they are used properly. We herein present a case of biguanide-associated severe lactic acidosis complicated with thiamine deficiency that was provoked without predisposing factors for thiamine deficiency. Diabetic patients taking biguanide may be predisposed to thiamine deficiency, even when there is no evidence of risk factors, and the high-dose administration of thiamine may be essential in the treatment of this otherwise under-recognized disorder.
  • |Acidosis, Lactic/chemically induced/*drug therapy/etiology [MESH]
  • |Aged [MESH]
  • |Biguanides/*adverse effects/therapeutic use [MESH]
  • |Diabetes Mellitus, Type 2/drug therapy [MESH]
  • |Dietary Supplements [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Hypoglycemic Agents/*adverse effects/therapeutic use [MESH]
  • |Risk Factors [MESH]
  • |Thiamine Deficiency/chemically induced/complications/drug therapy [MESH]


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