Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28202871
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Intern+Med
2017 ; 56
(4
): 455-459
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic
Acidosis Following Thiamine Supplementation
#MMPMID28202871
Godo S
; Yoshida Y
; Fujita M
; Kudo D
; Nomura R
; Shimokawa H
; Kushimoto S
Intern Med
2017[]; 56
(4
): 455-459
PMID28202871
show ga
Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus.
Although they can cause lactic acidosis in susceptible patients with predisposing
risk factors, the incidence of lactic acidosis is reported to be very low when
they are used properly. We herein present a case of biguanide-associated severe
lactic acidosis complicated with thiamine deficiency that was provoked without
predisposing factors for thiamine deficiency. Diabetic patients taking biguanide
may be predisposed to thiamine deficiency, even when there is no evidence of risk
factors, and the high-dose administration of thiamine may be essential in the
treatment of this otherwise under-recognized disorder.