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10.18632/oncotarget.12758 http://scihub22266oqcxt.onion/10.18632/oncotarget.12758 C5363612!5363612!27765910     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2016 ; 7 (47): 77664-82 Nephropedia Template TP {{tp|p=27765910|t=2016. Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo |pdf=|usr=}}{{27765910}} gab.com Text Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27765910 #FOAvip Mutation of p53 occasionally results in a gain of function, which promotes tumor growth. We asked whether destabilizing the gain-of-function protein would kill tumor cells. Downregulation of the gene reduced cell proliferation in p53-mutant cells, but not in p53-null cells, indicating that the former depended on the mutant protein for survival. Moreover, phenformin and 2-deoxyglucose suppressed cell growth and simultaneously destabilized mutant p53. The AMPK pathway, MAPK pathway, chaperone proteins and ubiquitination all contributed to this process. Interestingly, phenformin and 2-deoxyglucose also reduced tumor growth in syngeneic mice harboring the p53 mutation. Thus, destabilizing mutant p53 protein in order to kill cells exhibiting ?oncogene addiction? could be a promising strategy for combatting p53 mutant tumors. Twit Text FOAVip Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27765910 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27765910 #FOAvip English Wikipedia <ref>{{Cite pmid|27765910}}</ref> Suppression of gain-of-function mutant p53 with metabolic inhibitors reduces tumor growth in vivo #MMPMID27765910 Jung CL; Mun H; Jo SY; Oh JH; Lee C; Choi EK; Jang SJ; Suh YA Oncotarget 2016[Nov]; 7 (47): 77664-82 PMID27765910show ga Mutation of p53 occasionally results in a gain of function, which promotes tumor growth. We asked whether destabilizing the gain-of-function protein would kill tumor cells. Downregulation of the gene reduced cell proliferation in p53-mutant cells, but not in p53-null cells, indicating that the former depended on the mutant protein for survival. Moreover, phenformin and 2-deoxyglucose suppressed cell growth and simultaneously destabilized mutant p53. The AMPK pathway, MAPK pathway, chaperone proteins and ubiquitination all contributed to this process. Interestingly, phenformin and 2-deoxyglucose also reduced tumor growth in syngeneic mice harboring the p53 mutation. Thus, destabilizing mutant p53 protein in order to kill cells exhibiting ?oncogene addiction? could be a promising strategy for combatting p53 mutant tumors. äSuppression of gain-of-function mutant p53 with metabolic inhibitors r(epmc).pdf DeepDyve Pubget Overpricing