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10.18632/oncotarget.12680 http://scihub22266oqcxt.onion/10.18632/oncotarget.12680 C5363597!5363597 !27764808     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27764808 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (47 ): 77444-77456 Nephropedia Template TP {{tp|p=27764808 |t=2016. The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin s-lymphoma |pdf=|usr=}}{{27764808 }} gab.com Text The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin s-lymphoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27764808 #FOAvip Dysregulation of the apoptotic pathway is widely recognized as a key step in lymphomagenesis. Notably, LITAF was initially identified as a p53-inducible gene, subsequently implicated as a tumor suppressor. Our previous study also showed LITAF to be methylated in 89.5% B-NHL samples. Conversely, deregulated expression of BCL6 is a pathogenic event in many lymphomas. Interestingly, our study found an oppositional expression of LITAF and BCL6 in B-NHL. In addition, LITAF was recently identified as a novel target gene of BCL6. Therefore, we sought to explore the feedback loop between LITAF and BCL6 in B-NHL. Here, our data for the first time show that LITAF can repress expression of BCL6 by binding to Region A (-87 to +65) containing a putative LITAF-binding motif (CTCCC) within the BCL6 promoter. Furthermore, the regulation of BCL6 targets ( PRDM1 or c-Myc) by LITAF may be associated with B-cell differentiation. Results also demonstrate that ectopic expression of LITAF induces cell apoptosis, activated by releasing cytochrome c, cleaving PARP and caspase 3 in B-NHL cells whereas knockdown of LITAF robustly protected cells from apoptosis. Interestingly, BCL6, in turn, could reverse cell apoptosis mediated by LITAF. Collectively, our findings provide a novel apoptotic regulatory pathway in which LITAF, as a transcription factor, inhibits the expression of BCL6, which leads to activation of the intrinsic mitochondrial pathway and tumor apoptosis. Our study is expected to provide a possible biomarker as well as a target for clinical therapies to promote tumor cell apoptosis. Twit Text FOAVip The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin s-lymphoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27764808 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27764808 #FOAvip English Wikipedia <ref>{{Cite pmid|27764808 }}</ref> The feedback loop of LITAF and BCL6 is involved in regulating apoptosis in B cell non-Hodgkin s-lymphoma #MMPMID27764808 Shi Y ; Kuai Y ; Lei L ; Weng Y ; Berberich-Siebelt F ; Zhang X ; Wang J ; Zhou Y ; Jiang X ; Ren G ; Pan H ; Mao Z ; Zhou R Oncotarget 2016[Nov]; 7 (47 ): 77444-77456 PMID27764808 show ga Dysregulation of the apoptotic pathway is widely recognized as a key step in lymphomagenesis. Notably, LITAF was initially identified as a p53-inducible gene, subsequently implicated as a tumor suppressor. Our previous study also showed LITAF to be methylated in 89.5% B-NHL samples. Conversely, deregulated expression of BCL6 is a pathogenic event in many lymphomas. Interestingly, our study found an oppositional expression of LITAF and BCL6 in B-NHL. In addition, LITAF was recently identified as a novel target gene of BCL6. Therefore, we sought to explore the feedback loop between LITAF and BCL6 in B-NHL. Here, our data for the first time show that LITAF can repress expression of BCL6 by binding to Region A (-87 to +65) containing a putative LITAF-binding motif (CTCCC) within the BCL6 promoter. Furthermore, the regulation of BCL6 targets ( PRDM1 or c-Myc) by LITAF may be associated with B-cell differentiation. Results also demonstrate that ectopic expression of LITAF induces cell apoptosis, activated by releasing cytochrome c, cleaving PARP and caspase 3 in B-NHL cells whereas knockdown of LITAF robustly protected cells from apoptosis. Interestingly, BCL6, in turn, could reverse cell apoptosis mediated by LITAF. Collectively, our findings provide a novel apoptotic regulatory pathway in which LITAF, as a transcription factor, inhibits the expression of BCL6, which leads to activation of the intrinsic mitochondrial pathway and tumor apoptosis. Our study is expected to provide a possible biomarker as well as a target for clinical therapies to promote tumor cell apoptosis. |Apoptosis/*genetics [MESH] |B-Lymphocytes/*metabolism [MESH] |Cell Line, Tumor [MESH] |Gene Expression [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Lymphoma, Non-Hodgkin/*genetics/metabolism [MESH] |Mitochondria/genetics/metabolism [MESH] |Models, Biological [MESH] |Nuclear Proteins/*genetics/metabolism [MESH] |Protein Binding [MESH] |Proto-Oncogene Proteins c-bcl-6/*genetics/metabolism [MESH] |Signal Transduction [MESH] |Transcription Factors/*genetics/metabolism [MESH]The feedback loop of LITAF and BCL6 is involved in regulating apoptosi(epmc).pdf DeepDyve Pubget Overpricing