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The association between expression of IFIT1 in podocytes of MRL/lpr mice and the
renal pathological changes it causes: An animal study
#MMPMID27823966
Hu W
; Niu G
; Li H
; Gao H
; Kang R
; Chen X
; Lin L
Oncotarget
2016[Nov]; 7
(47
): 76464-76470
PMID27823966
show ga
Renal damage is the major cause of SLE associated mortality, and IFIT1expression
was elevated in SLE cases in accordance of previous studies. Therefore, we
conducted an animal study to identify the role of IFIT1 expression in renal
pathological changes.18 female MRL/lpr mice and same number of female BALB/c mice
were enrolled in present study. Quantitative analysis of urine protein,
Complement C3 and C4, and anti-ds DNA antibody were conducted. HE and PAS
staining and TEM analysis were employed to observe the pathological changes in
renal tissue. Significant elevation on urine protein and anti-dsDNA and reduction
on Complement C3 and C4 were observed in MRL/lpr mice when comparing the controls
in same age. Staining and TEM analysis observed several pathological changes in
glomerulus among MRL/lpr mice, including cellular enlargement, basement membrane
thickening, and increased cellularcasts. The linear regression analysis found the
optical density of IFIT1 was inversely associated with F-actin, Nephrin, and
Podocin, but not Synatopodin. In summary, IFIT1 expression is associated with
podocytes damage, and capable of suppressing some proteins essential to
glomerular filtration.
|Adaptor Proteins, Signal Transducing
[MESH]
|Animals
[MESH]
|Antibodies, Antinuclear/blood/immunology
[MESH]
|Biomarkers
[MESH]
|Carrier Proteins/*genetics/metabolism
[MESH]
|Complement System Proteins/immunology/metabolism
[MESH]
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