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10.1016/j.omtm.2016.12.006 http://scihub22266oqcxt.onion/10.1016/j.omtm.2016.12.006 C5363291!5363291!28344995     free     free     free       Mol+Ther+Methods+Clin+Dev 2017 ; 4 (ä): 92-101 Nephropedia Template TP {{tp|p=28344995|t=2017. Global Manufacturing of CAR T Cell Therapy |pdf=|usr=}}{{28344995}} gab.com Text Global Manufacturing of CAR T Cell Therapy JO: Mol Ther Methods Clin Dev http://www.kidney.de/pget.php?&tw=1&pmid=28344995 #FOAvip Immunotherapy using chimeric antigen receptor-modified T cells has demonstrated high response rates in patients with B cell malignancies, and chimeric antigen receptor T cell therapy is now being investigated in several hematologic and solid tumor types. Chimeric antigen receptor T cells are generated by removing T cells from a patient?s blood and engineering the cells to express the chimeric antigen receptor, which reprograms the T cells to target tumor cells. As chimeric antigen receptor T cell therapy moves into later-phase clinical trials and becomes an option for more patients, compliance of the chimeric antigen receptor T cell manufacturing process with global regulatory requirements becomes a topic for extensive discussion. Additionally, the challenges of taking a chimeric antigen receptor T cell manufacturing process from a single institution to a large-scale multi-site manufacturing center must be addressed. We have anticipated such concerns in our experience with the CD19 chimeric antigen receptor T cell therapy CTL019. In this review, we discuss steps involved in the cell processing of the technology, including the use of an optimal vector for consistent cell processing, along with addressing the challenges of expanding chimeric antigen receptor T cell therapy to a global patient population. Twit Text FOAVip Global Manufacturing of CAR T Cell Therapy ????Mol Ther Methods Clin Dev http://www.kidney.de/pget.php?&tw=1&pmid=28344995 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28344995 #FOAvip English Wikipedia <ref>{{Cite pmid|28344995}}</ref> Global Manufacturing of CAR T Cell Therapy #MMPMID28344995 Levine BL; Miskin J; Wonnacott K; Keir C Mol Ther Methods Clin Dev 2017[Mar]; 4 (ä): 92-101 PMID28344995show ga Immunotherapy using chimeric antigen receptor-modified T cells has demonstrated high response rates in patients with B cell malignancies, and chimeric antigen receptor T cell therapy is now being investigated in several hematologic and solid tumor types. Chimeric antigen receptor T cells are generated by removing T cells from a patient?s blood and engineering the cells to express the chimeric antigen receptor, which reprograms the T cells to target tumor cells. As chimeric antigen receptor T cell therapy moves into later-phase clinical trials and becomes an option for more patients, compliance of the chimeric antigen receptor T cell manufacturing process with global regulatory requirements becomes a topic for extensive discussion. Additionally, the challenges of taking a chimeric antigen receptor T cell manufacturing process from a single institution to a large-scale multi-site manufacturing center must be addressed. We have anticipated such concerns in our experience with the CD19 chimeric antigen receptor T cell therapy CTL019. In this review, we discuss steps involved in the cell processing of the technology, including the use of an optimal vector for consistent cell processing, along with addressing the challenges of expanding chimeric antigen receptor T cell therapy to a global patient population. äGlobal Manufacturing of CAR T Cell Therapy (epmc).pdf DeepDyve Pubget Overpricing