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10.1038/srep45192 http://scihub22266oqcxt.onion/10.1038/srep45192 C5362910!5362910 !28332628     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28332628 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 45192 Nephropedia Template TP {{tp|p=28332628 |t=2017. Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings |pdf=|usr=}}{{28332628 }} gab.com Text Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28332628 #FOAvip This study aimed to investigate the protective effects of EGb761, a Ginkgo Biloba extract, against brain death-induced kidney injury. Sixty male Sprague Dawley rats were randomly divided into six groups: sham, brain-death (BD), BD?+?EGb b48h (48?hours before BD), BD?+?EGb 2?h (2?hours after BD), BD?+?EGb 1?h, and BD?+?EGb 0.5?h. Six hours after BD, serum sample and kidney tissues were collected for analyses. The levels of blood urea nitrogen (BUN) and serum creatinine significantly elevated in the BD group than in sham group. In all the EGb761-treated BD animals except for the BD?+?Gb 2?h group, the levels of BUN and serum creatinine significantly reduced (all P?<?0.01). EGb761 attenuated tubular injury and lowered the histological score. In addition, the longer duration of drug treatment was, the better protective efficacy could be observed. EGb761 significantly reduced IL-1?, IL-6, TNF-?, MCP-1, IP-10 mRNA expression and macrophage infiltration in the kidney. EGb761 treatment at 48?hour before brain death significantly attenuate the levels of p-JNK-MAPK, p-p38-MAPK, and p-STAT3 proteins (all P?<?0.05, compared to BD group). In summary, our data showed that EGb761 treatment protected donor kidney from BD-induced damages by blocking SAPK and JAK-STAT signalings. Early administration of EGb761 can provide better protective efficacy. Twit Text FOAVip Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28332628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28332628 #FOAvip English Wikipedia <ref>{{Cite pmid|28332628 }}</ref> Ginkgo biloba extract EGb761 attenuates brain death-induced renal injury by inhibiting pro-inflammatory cytokines and the SAPK and JAK-STAT signalings #MMPMID28332628 Li Y ; Xiong Y ; Zhang H ; Li J ; Wang D ; Chen W ; Yuan X ; Su Q ; Li W ; Huang H ; Bi Z ; Liu L ; Wang C Sci Rep 2017[Mar]; 7 (ä): 45192 PMID28332628 show ga This study aimed to investigate the protective effects of EGb761, a Ginkgo Biloba extract, against brain death-induced kidney injury. Sixty male Sprague Dawley rats were randomly divided into six groups: sham, brain-death (BD), BD?+?EGb b48h (48?hours before BD), BD?+?EGb 2?h (2?hours after BD), BD?+?EGb 1?h, and BD?+?EGb 0.5?h. Six hours after BD, serum sample and kidney tissues were collected for analyses. The levels of blood urea nitrogen (BUN) and serum creatinine significantly elevated in the BD group than in sham group. In all the EGb761-treated BD animals except for the BD?+?Gb 2?h group, the levels of BUN and serum creatinine significantly reduced (all P? |Acute Kidney Injury/*drug therapy/etiology/prevention & control [MESH] |Animals [MESH] |Anti-Inflammatory Agents/*therapeutic use [MESH] |Brain Death/blood/*metabolism [MESH] |Cytokines/genetics/*metabolism [MESH] |Ginkgo biloba [MESH] |Kidney Transplantation/*adverse effects [MESH] |Kidney/metabolism/pathology [MESH] |MAP Kinase Signaling System [MESH] |Male [MESH] |Plant Extracts/*therapeutic use [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |STAT Transcription Factors/metabolism [MESH] |Tissue Donors [MESH]Ginkgo biloba extract EGb761 attenuates brain death-induced renal inju(epmc).pdf DeepDyve Pubget Overpricing