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10.1016/j.ajpath.2013.08.024 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2013.08.024 C5362691!5362691 !24266925     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24266925 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Pathol 2013 ; 183 (6 ): 1740-1746 Nephropedia Template TP {{tp|p=24266925 |t=2013. Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis |pdf=|usr=}}{{24266925 }} gab.com Text Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24266925 #FOAvip Adenosine has an important role in inflammation and tissue remodeling and promotes dermal fibrosis by adenosine receptor (A2AR) activation. Adenosine may be formed intracellularly from adenine nucleotides or extracellularly through sequential phosphohydrolysis of released ATP by nucleoside triphosphate diphosphohydrolase (CD39) and ecto-5'-nucleotidase (CD73). Because the role of these ecto-enzymes in fibrosis appears to be tissue specific, we determined whether these ectonucleotidases were directly involved in diffuse dermal fibrosis. Wild-type and mice globally deficient in CD39 knockout (CD39KO), CD73 (CD73KO), or both (CD39/CD73DKO) were challenged with bleomycin. Extracellular adenosine levels and dermal fibrosis were quantitated. Adenosine release from skin cultured ex vivo was increased in wild-type mice after bleomycin treatment but remained low in skin from CD39KO, CD73KO, or CD39/CD73DKO bleomycin-treated mice. Deletion of CD39 and/or CD73 decreased the collagen content, and prevented skin thickening and tensile strength increase after bleomycin challenge. Decreased dermal fibrotic features were associated with reduced expression of the profibrotic mediators, transforming growth factor-?1 and connective tissue growth factor, and diminished myofibroblast population in CD39- and/or CD73-deficient mice. Our work supports the hypothesis that extracellular adenosine, generated in tandem by ecto-enzymes CD39 and CD73, promotes dermal fibrogenesis. We suggest that biochemical or biological inhibitors of CD39 and/or CD73 may hold promise in the treatment of dermal fibrosis in diseases such as scleroderma. Twit Text FOAVip Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=24266925 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24266925 #FOAvip English Wikipedia <ref>{{Cite pmid|24266925 }}</ref> Extracellular generation of adenosine by the ectonucleotidases CD39 and CD73 promotes dermal fibrosis #MMPMID24266925 Fernández P ; Perez-Aso M ; Smith G ; Wilder T ; Trzaska S ; Chiriboga L ; Franks A Jr ; Robson SC ; Cronstein BN ; Chan ESL Am J Pathol 2013[Dec]; 183 (6 ): 1740-1746 PMID24266925 show ga Adenosine has an important role in inflammation and tissue remodeling and promotes dermal fibrosis by adenosine receptor (A2AR) activation. Adenosine may be formed intracellularly from adenine nucleotides or extracellularly through sequential phosphohydrolysis of released ATP by nucleoside triphosphate diphosphohydrolase (CD39) and ecto-5'-nucleotidase (CD73). Because the role of these ecto-enzymes in fibrosis appears to be tissue specific, we determined whether these ectonucleotidases were directly involved in diffuse dermal fibrosis. Wild-type and mice globally deficient in CD39 knockout (CD39KO), CD73 (CD73KO), or both (CD39/CD73DKO) were challenged with bleomycin. Extracellular adenosine levels and dermal fibrosis were quantitated. Adenosine release from skin cultured ex vivo was increased in wild-type mice after bleomycin treatment but remained low in skin from CD39KO, CD73KO, or CD39/CD73DKO bleomycin-treated mice. Deletion of CD39 and/or CD73 decreased the collagen content, and prevented skin thickening and tensile strength increase after bleomycin challenge. Decreased dermal fibrotic features were associated with reduced expression of the profibrotic mediators, transforming growth factor-?1 and connective tissue growth factor, and diminished myofibroblast population in CD39- and/or CD73-deficient mice. Our work supports the hypothesis that extracellular adenosine, generated in tandem by ecto-enzymes CD39 and CD73, promotes dermal fibrogenesis. We suggest that biochemical or biological inhibitors of CD39 and/or CD73 may hold promise in the treatment of dermal fibrosis in diseases such as scleroderma. |*5'-Nucleotidase/genetics/metabolism [MESH] |*Adenosine/genetics/metabolism [MESH] |*Antigens, CD/genetics/metabolism [MESH] |*Apyrase/genetics/metabolism [MESH] |*Dermis/metabolism/pathology [MESH] |*Scleroderma, Systemic/chemically induced/genetics/metabolism/pathology [MESH] |Animals [MESH] |Antibiotics, Antineoplastic/adverse effects/pharmacology [MESH] |Bleomycin/adverse effects/pharmacology [MESH] |Fibrosis/chemically induced/genetics/metabolism/pathology [MESH] |Mice [MESH] |Mice, Knockout [MESH]Extracellular generation of adenosine by the ectonucleotidases CD39 an(epmc).pdf DeepDyve Pubget Overpricing