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10.1007/s00424-017-1944-8 http://scihub22266oqcxt.onion/10.1007/s00424-017-1944-8 C5362662!5362662 !28251312     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28251312 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Pflugers+Arch 2017 ; 469 (3-4 ): 397-418 Nephropedia Template TP {{tp|p=28251312 |t=2017. "Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels |pdf=|usr=}}{{28251312 }} gab.com Text "Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels JO: Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=28251312 #FOAvip Macrophages reside in virtually every organ. First arising during embryogenesis, macrophages replenish themselves in the adult through a combination of self-renewal and influx of bone marrow-derived monocytes. As large phagocytic cells, macrophages participate in innate immunity while contributing to tissue-specific homeostatic functions. Among the key metabolic tasks are senescent red blood cell recycling, free heme detoxification, and provision of iron for de novo hemoglobin synthesis. While this systemic mechanism involves the shuttling of iron between spleen, liver, and bone marrow through the concerted function of defined macrophage populations, similar circuits appear to exist within the microenvironment of other organs. The high turnover of iron is the prerequisite for continuous erythropoiesis and tissue integrity but challenges macrophages' ability to maintain cellular iron homeostasis and immune function.This review provides a brief overview of systemic, microenvironmental, and cellular aspects of macrophage iron handling with a focus on exciting and unresolved questions in the field. Twit Text FOAVip "Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels ????Pflugers Arch http://www.kidney.de/pget.php?&tw=1&pmid=28251312 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28251312 #FOAvip English Wikipedia <ref>{{Cite pmid|28251312 }}</ref> "Pumping iron"-how macrophages handle iron at the systemic, microenvironmental, and cellular levels #MMPMID28251312 Nairz M ; Theurl I ; Swirski FK ; Weiss G Pflugers Arch 2017[Apr]; 469 (3-4 ): 397-418 PMID28251312 show ga Macrophages reside in virtually every organ. First arising during embryogenesis, macrophages replenish themselves in the adult through a combination of self-renewal and influx of bone marrow-derived monocytes. As large phagocytic cells, macrophages participate in innate immunity while contributing to tissue-specific homeostatic functions. Among the key metabolic tasks are senescent red blood cell recycling, free heme detoxification, and provision of iron for de novo hemoglobin synthesis. While this systemic mechanism involves the shuttling of iron between spleen, liver, and bone marrow through the concerted function of defined macrophage populations, similar circuits appear to exist within the microenvironment of other organs. The high turnover of iron is the prerequisite for continuous erythropoiesis and tissue integrity but challenges macrophages' ability to maintain cellular iron homeostasis and immune function.This review provides a brief overview of systemic, microenvironmental, and cellular aspects of macrophage iron handling with a focus on exciting and unresolved questions in the field. |Animals [MESH] |Cellular Microenvironment/*physiology [MESH] |Erythropoiesis/physiology [MESH] |Homeostasis/physiology [MESH] |Humans [MESH] |Iron/*metabolism [MESH]"Pumping iron"-how macrophages handle iron at the systemic, microenvir(epmc).pdf DeepDyve Pubget Overpricing