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10.1007/s12079-016-0358-2 http://scihub22266oqcxt.onion/10.1007/s12079-016-0358-2 C5362571!5362571!27766493     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Commun+Signal 2017 ; 11 (1): 39-48 Nephropedia Template TP {{tp|p=27766493|t=2017. CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy |pdf=|usr=}}{{27766493}} gab.com Text CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy JO: J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=27766493 #FOAvip Treatment with rhBMP7 exerts profound protective effects in a wide variety of experimental models of renal disease. However, little is known about how these protective effects are mediated, and which cells in the kidney are targeted by exogenous rhBMP7 treatment. To determine if rhBMP7 increases glomerular and tubulointerstitial canonical BMP signaling, we performed Unilateral Ureteral Obstruction (UUO, a widely used obstructive nephropathy model) in mice reporting transcriptional activity downstream of canonical BMP signaling by the expression of GFP under the BMP Responsive Element of the Id1 promoter (BRE:gfp mice). We also analysed the impact of rhBMP7 treatment on severity of the UUO phenotype, on TGF? signaling, and on expression of CCN2 (CTGF). Despite profound protective effects with respect to morphological damage, macrophage infiltration, and fibrosis, no significant difference in GFP-expression was observed upon rhBMP7 administration. Also TGF? signalling was similar in rhBMP7 and vehicle treated mice, but CCN2 expression in obstructed kidneys was significantly reduced by rhBMP7 treatment. Of note, in heterozygous CCN2 mice (CCN2+/?) treatment with rhBMP7 did not (further) reduce the severity of kidney damage in the UUO-model. These data suggest that protection against obstructive nephropathy by exogenous rhBMP7 treatment relies primarily on non-canonical BMP signaling, and may be mediated in large part by downregulation of CCN2 expression.Electronic supplementary material: The online version of this article (doi:10.1007/s12079-016-0358-2) contains supplementary material, which is available to authorized users. Twit Text FOAVip CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy ????J Cell Commun Signal http://www.kidney.de/pget.php?&tw=1&pmid=27766493 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27766493 #FOAvip English Wikipedia <ref>{{Cite pmid|27766493}}</ref> CCN2 reduction mediates protective effects of BMP7 treatment in obstructive nephropathy #MMPMID27766493 Falke LL; Leeuwis JW; Lyons KM; Mummery CL; Nguyen TQ; Goldschmeding R J Cell Commun Signal 2017[Mar]; 11 (1): 39-48 PMID27766493show ga Treatment with rhBMP7 exerts profound protective effects in a wide variety of experimental models of renal disease. However, little is known about how these protective effects are mediated, and which cells in the kidney are targeted by exogenous rhBMP7 treatment. To determine if rhBMP7 increases glomerular and tubulointerstitial canonical BMP signaling, we performed Unilateral Ureteral Obstruction (UUO, a widely used obstructive nephropathy model) in mice reporting transcriptional activity downstream of canonical BMP signaling by the expression of GFP under the BMP Responsive Element of the Id1 promoter (BRE:gfp mice). We also analysed the impact of rhBMP7 treatment on severity of the UUO phenotype, on TGF? signaling, and on expression of CCN2 (CTGF). Despite profound protective effects with respect to morphological damage, macrophage infiltration, and fibrosis, no significant difference in GFP-expression was observed upon rhBMP7 administration. Also TGF? signalling was similar in rhBMP7 and vehicle treated mice, but CCN2 expression in obstructed kidneys was significantly reduced by rhBMP7 treatment. Of note, in heterozygous CCN2 mice (CCN2+/?) treatment with rhBMP7 did not (further) reduce the severity of kidney damage in the UUO-model. These data suggest that protection against obstructive nephropathy by exogenous rhBMP7 treatment relies primarily on non-canonical BMP signaling, and may be mediated in large part by downregulation of CCN2 expression.Electronic supplementary material: The online version of this article (doi:10.1007/s12079-016-0358-2) contains supplementary material, which is available to authorized users. äCCN2 reduction mediates protective effects of BMP7 treatment in obstru(epmc).pdf DeepDyve Pubget Overpricing