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10.18632/oncotarget.13278 http://scihub22266oqcxt.onion/10.18632/oncotarget.13278 C5362539!5362539!27852056     free     free     free       Oncotarget 2017 ; 8 (9): 15971-6 Nephropedia Template TP {{tp|p=27852056|t=2017. TLE1 function and therapeutic potential in cancer |pdf=|usr=}}{{27852056}} gab.com Text TLE1 function and therapeutic potential in cancer JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27852056 #FOAvip Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 could be used as a diagnostic marker and is a possible therapeutic target in various malignancies. It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In this review, we highlight the functions of TLE1 in cancer and explore targeted approaches for cancer diagnosis and treatment. In particular, we discuss the TLE1 function in pancreatic cancer. Twit Text FOAVip TLE1 function and therapeutic potential in cancer ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27852056 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27852056 #FOAvip English Wikipedia <ref>{{Cite pmid|27852056}}</ref> TLE1 function and therapeutic potential in cancer #MMPMID27852056 Yuan D; Yang X; Yuan Z; Zhao Y; Guo J Oncotarget 2017[Feb]; 8 (9): 15971-6 PMID27852056show ga Groucho (Gro)/Transducin-like enhancer of split (TLE) family proteins act as co-repressors of many transcription factors, and are involved in key signaling pathways. TLE1 negatively regulates inflammation and has potential roles in various diseases, including cancer. Previous studies suggest TLE1 could be used as a diagnostic marker and is a possible therapeutic target in various malignancies. It is therefore important to elucidate the mechanisms underlying TLE1 function during cancer initiation and metastasis. In this review, we highlight the functions of TLE1 in cancer and explore targeted approaches for cancer diagnosis and treatment. In particular, we discuss the TLE1 function in pancreatic cancer. äTLE1 function and therapeutic potential in cancer (epmc).pdf DeepDyve Pubget Overpricing