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10.18632/oncotarget.14948 http://scihub22266oqcxt.onion/10.18632/oncotarget.14948 C5362505!5362505 !28152519     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28152519 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (9 ): 15553-15562 Nephropedia Template TP {{tp|p=28152519 |t=2017. Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria |pdf=|usr=}}{{28152519 }} gab.com Text Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28152519 #FOAvip Despite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin- System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular function are needed to assess patients' condition and help deciding future therapies.Proteomic analysis of circulating extracellular vesicles (EVs) showed two proteins, kalirin and chromodomain-helicase-DNA-binding protein 7 (CHD7), increased in albuminuric patients. A positive correlation of both with the expression of the endothelial activation marker E-selectin was found in EVs. In vitro analysis using TNF?-treated adult human endothelial cells proved their involvement in endothelial cell activation.Hence, we propose protein levels of kalirin and CHD7 in circulating EVs as novel endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria. Twit Text FOAVip Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28152519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28152519 #FOAvip English Wikipedia <ref>{{Cite pmid|28152519 }}</ref> Kalirin and CHD7: novel endothelial dysfunction indicators in circulating extracellular vesicles from hypertensive patients with albuminuria #MMPMID28152519 de la Cuesta F ; Baldan-Martin M ; Moreno-Luna R ; Alvarez-Llamas G ; Gonzalez-Calero L ; Mourino-Alvarez L ; Sastre-Oliva T ; López JA ; Vázquez J ; Ruiz-Hurtado G ; Segura J ; Vivanco F ; Ruilope LM ; Barderas MG Oncotarget 2017[Feb]; 8 (9 ): 15553-15562 PMID28152519 show ga Despite of the great advances in anti-hypertensive therapies, many patients under Renin-Angiotensin- System (RAS) suppression develop albuminuria, which is a clear indicator of therapeutic inefficiency. Hence, indicators of vascular function are needed to assess patients' condition and help deciding future therapies.Proteomic analysis of circulating extracellular vesicles (EVs) showed two proteins, kalirin and chromodomain-helicase-DNA-binding protein 7 (CHD7), increased in albuminuric patients. A positive correlation of both with the expression of the endothelial activation marker E-selectin was found in EVs. In vitro analysis using TNF?-treated adult human endothelial cells proved their involvement in endothelial cell activation.Hence, we propose protein levels of kalirin and CHD7 in circulating EVs as novel endothelial dysfunction markers to monitor vascular condition in hypertensive patients with albuminuria. |Aged [MESH] |Albuminuria/blood/*metabolism [MESH] |Biomarkers/blood/metabolism [MESH] |DNA Helicases/*metabolism [MESH] |DNA-Binding Proteins/*metabolism [MESH] |E-Selectin/metabolism [MESH] |Endothelial Cells/drug effects/metabolism [MESH] |Endothelium, Vascular/metabolism/pathology/physiopathology [MESH] |Extracellular Vesicles/*metabolism/ultrastructure [MESH] |Female [MESH] |Guanine Nucleotide Exchange Factors/*metabolism [MESH] |Humans [MESH] |Hypertension/blood/*metabolism [MESH] |Male [MESH] |Microscopy, Confocal [MESH] |Microscopy, Electron [MESH] |Middle Aged [MESH] |Protein Serine-Threonine Kinases/*metabolism [MESH] |Proteomics/methods [MESH]Kalirin and CHD7: novel endothelial dysfunction indicators in circulat(epmc).pdf DeepDyve Pubget Overpricing