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10.18632/oncotarget.14695 http://scihub22266oqcxt.onion/10.18632/oncotarget.14695 C5362504!5362504 !28107184     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28107184 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (9 ): 15539-15552 Nephropedia Template TP {{tp|p=28107184 |t=2017. Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells |pdf=|usr=}}{{28107184 }} gab.com Text Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28107184 #FOAvip Intercellular transfer of organelles via tunneling nanotubes (TNTs) is a novel means of cell-to-cell communication. Here we demonstrate the existence of TNTs between co-cultured RT4 and T24 bladder cancer cells using light microscopy, fluorescence imaging, and scanning electron microscopy (SEM). Spontaneous unidirectional transfer of mitochondria from T24 to RT4 cells was detected using fluorescence imaging and flow cytometry. The distribution of mitochondria migrated from T24 cells was in good agreement with the original mitochondria in RT4 cells, which may imply mitochondrial fusion. We detected cytoskeleton reconstruction in RT4-Mito-T24 cells by observing F-actin redistribution. Akt, mTOR, and their downstream mediators were activated and increased. The resultant increase in the invasiveness of bladder cancer cells was detected in vitro and in vivo. These data indicate that TNTs promote intercellular mitochondrial transfer between heterogeneous cells, followed by an increase in the invasiveness of bladder cancer cells. Twit Text FOAVip Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28107184 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28107184 #FOAvip English Wikipedia <ref>{{Cite pmid|28107184 }}</ref> Tunneling nanotubes promote intercellular mitochondria transfer followed by increased invasiveness in bladder cancer cells #MMPMID28107184 Lu J ; Zheng X ; Li F ; Yu Y ; Chen Z ; Liu Z ; Wang Z ; Xu H ; Yang W Oncotarget 2017[Feb]; 8 (9 ): 15539-15552 PMID28107184 show ga Intercellular transfer of organelles via tunneling nanotubes (TNTs) is a novel means of cell-to-cell communication. Here we demonstrate the existence of TNTs between co-cultured RT4 and T24 bladder cancer cells using light microscopy, fluorescence imaging, and scanning electron microscopy (SEM). Spontaneous unidirectional transfer of mitochondria from T24 to RT4 cells was detected using fluorescence imaging and flow cytometry. The distribution of mitochondria migrated from T24 cells was in good agreement with the original mitochondria in RT4 cells, which may imply mitochondrial fusion. We detected cytoskeleton reconstruction in RT4-Mito-T24 cells by observing F-actin redistribution. Akt, mTOR, and their downstream mediators were activated and increased. The resultant increase in the invasiveness of bladder cancer cells was detected in vitro and in vivo. These data indicate that TNTs promote intercellular mitochondrial transfer between heterogeneous cells, followed by an increase in the invasiveness of bladder cancer cells. |Actins/metabolism [MESH] |Animals [MESH] |Biological Transport [MESH] |Blotting, Western [MESH] |Cell Communication [MESH] |Cell Line, Tumor [MESH] |Cell Movement [MESH] |Coculture Techniques [MESH] |Cytoskeleton/*metabolism [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Male [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |Microscopy, Electron, Scanning [MESH] |Microscopy, Fluorescence [MESH] |Mitochondria/*metabolism [MESH] |Nanotubes/*chemistry/ultrastructure [MESH] |Neoplasm Invasiveness [MESH] |Proto-Oncogene Proteins c-akt/metabolism [MESH] |Signal Transduction [MESH] |TOR Serine-Threonine Kinases/metabolism [MESH] |Transplantation, Heterologous [MESH]Tunneling nanotubes promote intercellular mitochondria transfer follow(epmc).pdf DeepDyve Pubget Overpricing