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10.18632/oncotarget.14839 http://scihub22266oqcxt.onion/10.18632/oncotarget.14839 C5362483!5362483 !28146425     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28146425 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (9 ): 15242-15251 Nephropedia Template TP {{tp|p=28146425 |t=2017. Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression |pdf=|usr=}}{{28146425 }} gab.com Text Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28146425 #FOAvip Here we demonstrated that Galectin-3 protein level was frequently up-regulated in colorectal cancer (CRC) cells and tissues. Galectin-3 up-regulation correlated with CRC progression and predicted a shorter overall survival of CRC patients. Galectin-3 overexpression attenuated the chemo-sensitivity of cancer cells, but enhanced the potential invasiveness. To explore the mechanism for Galectin-3 dysregulation, we found that miR-128 level was frequently down-regulated in CRC and negatively correlated with Galectin-3 level. Using bioinformatics analysis and experimental validation, we showed that miR-128 could directly target Galectin-3 to repress its protein level. MiR-128 decrease associated with CRC progression and predicted a worse overall survival of CRC patients. Ectopic miR-128 expression enhanced the chemo-sensitivity of CRC cells in vitro and in vivo, and inhibited the potential invasiveness. Galectin-3 expression impaired the cancer suppressive effects of miR-128. These data highlighted the role of miR-128/Galectin-3 axis in colorectal cancer. Twit Text FOAVip Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28146425 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28146425 #FOAvip English Wikipedia <ref>{{Cite pmid|28146425 }}</ref> Posttranscriptional regulation of Galectin-3 by miR-128 contributes to colorectal cancer progression #MMPMID28146425 Lu W ; Wang J ; Yang G ; Yu N ; Huang Z ; Xu H ; Li J ; Qiu J ; Zeng X ; Chen S ; Li N ; Liu H Oncotarget 2017[Feb]; 8 (9 ): 15242-15251 PMID28146425 show ga Here we demonstrated that Galectin-3 protein level was frequently up-regulated in colorectal cancer (CRC) cells and tissues. Galectin-3 up-regulation correlated with CRC progression and predicted a shorter overall survival of CRC patients. Galectin-3 overexpression attenuated the chemo-sensitivity of cancer cells, but enhanced the potential invasiveness. To explore the mechanism for Galectin-3 dysregulation, we found that miR-128 level was frequently down-regulated in CRC and negatively correlated with Galectin-3 level. Using bioinformatics analysis and experimental validation, we showed that miR-128 could directly target Galectin-3 to repress its protein level. MiR-128 decrease associated with CRC progression and predicted a worse overall survival of CRC patients. Ectopic miR-128 expression enhanced the chemo-sensitivity of CRC cells in vitro and in vivo, and inhibited the potential invasiveness. Galectin-3 expression impaired the cancer suppressive effects of miR-128. These data highlighted the role of miR-128/Galectin-3 axis in colorectal cancer. |Animals [MESH] |Antineoplastic Agents/pharmacology [MESH] |Apoptosis [MESH] |Biomarkers, Tumor/genetics/metabolism [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Colorectal Neoplasms/genetics/metabolism/*pathology [MESH] |Disease Progression [MESH] |Drug Resistance, Neoplasm/*genetics [MESH] |Female [MESH] |Follow-Up Studies [MESH] |Galectin 3/genetics/*metabolism [MESH] |Humans [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Mice, Nude [MESH] |MicroRNAs/*genetics [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Staging [MESH] |Prognosis [MESH] |RNA Processing, Post-Transcriptional/*genetics [MESH] |Survival Rate [MESH] |Tumor Cells, Cultured [MESH]Posttranscriptional regulation of Galectin-3 by miR-128 contributes to(epmc).pdf DeepDyve Pubget Overpricing