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10.18632/oncotarget.11102 http://scihub22266oqcxt.onion/10.18632/oncotarget.11102 C5362410!5362410!27527869     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (9): 14343-58 Nephropedia Template TP {{tp|p=27527869|t=2017. Epithelial membrane protein 3 regulates TGF-? signaling activation in CD44-high glioblastoma |pdf=|usr=}}{{27527869}} gab.com Text Epithelial membrane protein 3 regulates TGF- signaling activation in CD44-high glioblastoma JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27527869 #FOAvip Although epithelial membrane protein 3 (EMP3) has been implicated as a candidate tumor suppressor gene for low grade glioma, its biological function in glioblastoma multiforme (GBM) still remains poorly understood. Herein, we showed that EMP3 was highly expressed in CD44-high primary GBMs. Depletion of EMP3 expression suppressed cell proliferation, impaired in vitro tumorigenic potential and induced apoptosis in CD44-high GBM cell lines. We also identified TGF-?/Smad2/3 signaling pathway as a potential target of EMP3. EMP3 interacts with TGF-?receptor type 2 (TGFBR2) upon TGF-?stimulation in GBM cells. Consequently, the EMP3-TGFBR2 interaction regulates TGF-?/Smad2/3 signaling activation and positively impacts on TGF-?stimulated gene expression and cell proliferation in vitro and in vivo. Highly correlated protein expression of EMP3 and TGF-?/Smad2/3 signaling pathway components was also observed in GBM specimens, confirming the clinical relevancy of activated EMP3/TGF-?/Smad2/3 signaling in GBM. In conclusion, our findings revealed that EMP3 might be a potential target for CD44-high GBMs and highlight the essential functions of EMP3 in TGF-?/Smad2/3 signaling activation and tumor progression. Twit Text FOAVip Epithelial membrane protein 3 regulates TGF- signaling activation in CD44-high glioblastoma ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27527869 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27527869 #FOAvip English Wikipedia <ref>{{Cite pmid|27527869}}</ref> Epithelial membrane protein 3 regulates TGF-? signaling activation in CD44-high glioblastoma #MMPMID27527869 Jun F; Hong J; Liu Q; Guo Y; Liao Y; Huang J; Wen S; Shen L Oncotarget 2017[Feb]; 8 (9): 14343-58 PMID27527869show ga Although epithelial membrane protein 3 (EMP3) has been implicated as a candidate tumor suppressor gene for low grade glioma, its biological function in glioblastoma multiforme (GBM) still remains poorly understood. Herein, we showed that EMP3 was highly expressed in CD44-high primary GBMs. Depletion of EMP3 expression suppressed cell proliferation, impaired in vitro tumorigenic potential and induced apoptosis in CD44-high GBM cell lines. We also identified TGF-?/Smad2/3 signaling pathway as a potential target of EMP3. EMP3 interacts with TGF-?receptor type 2 (TGFBR2) upon TGF-?stimulation in GBM cells. Consequently, the EMP3-TGFBR2 interaction regulates TGF-?/Smad2/3 signaling activation and positively impacts on TGF-?stimulated gene expression and cell proliferation in vitro and in vivo. Highly correlated protein expression of EMP3 and TGF-?/Smad2/3 signaling pathway components was also observed in GBM specimens, confirming the clinical relevancy of activated EMP3/TGF-?/Smad2/3 signaling in GBM. In conclusion, our findings revealed that EMP3 might be a potential target for CD44-high GBMs and highlight the essential functions of EMP3 in TGF-?/Smad2/3 signaling activation and tumor progression. äEpithelial membrane protein 3 regulates TGF-? signaling activation in (epmc).pdf DeepDyve Pubget Overpricing