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10.18632/oncotarget.15093 http://scihub22266oqcxt.onion/10.18632/oncotarget.15093 C5362405!5362405 !28179581     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28179581 &cmd=llinks): Failed to open stream: HTTP request failed! 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Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases |pdf=|usr=}}{{28179581 }} gab.com Text Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28179581 #FOAvip Abdominal aortic aneurysm (AAA) affects more than 5% of the population in developed countries and the pharmacotherapies for AAA are limited. Here, we explored whether melatonin regulates the development of AAA. In smooth muscle cells, melatonin treatment decreases angiotensin II-induced matrix metalloproteinase 2 (MMP2) and MMP9 expression. Human antigen R (HuR) could bind with the adenylateuridylate-rich elements of MMP2 and MMP9 mRNAs 3' untranslated region, resulting in the increased stability of MMP2 and MMP9 mRNAs. HuR is required for angiotensin II-induced MMP2 and MMP9 expression. Moreover, melatonin suppresses angiotensin II-induced HuR expression through inhibiting NF-?B signaling, leading to decreased MMP2 and MMP9 levels. Finally, melatonin attenuates the development of AAA in ApoE-/- mice infused with angiotensin II in vivo. These data support a role of HuR in the development of AAA and possible therapeutic roles for melatonin and/or HuR inhibition in AAA. Twit Text FOAVip Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28179581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28179581 #FOAvip English Wikipedia <ref>{{Cite pmid|28179581 }}</ref> Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm through the down-regulation of matrix metalloproteinases #MMPMID28179581 Kong J ; Zhang Y ; Liu S ; Li H ; Liu S ; Wang J ; Qin X ; Jiang X ; Yang J ; Zhang C ; Zhang W Oncotarget 2017[Feb]; 8 (9 ): 14283-14293 PMID28179581 show ga Abdominal aortic aneurysm (AAA) affects more than 5% of the population in developed countries and the pharmacotherapies for AAA are limited. Here, we explored whether melatonin regulates the development of AAA. In smooth muscle cells, melatonin treatment decreases angiotensin II-induced matrix metalloproteinase 2 (MMP2) and MMP9 expression. Human antigen R (HuR) could bind with the adenylateuridylate-rich elements of MMP2 and MMP9 mRNAs 3' untranslated region, resulting in the increased stability of MMP2 and MMP9 mRNAs. HuR is required for angiotensin II-induced MMP2 and MMP9 expression. Moreover, melatonin suppresses angiotensin II-induced HuR expression through inhibiting NF-?B signaling, leading to decreased MMP2 and MMP9 levels. Finally, melatonin attenuates the development of AAA in ApoE-/- mice infused with angiotensin II in vivo. These data support a role of HuR in the development of AAA and possible therapeutic roles for melatonin and/or HuR inhibition in AAA. |Angiotensin II/*toxicity [MESH] |Animals [MESH] |Antioxidants/pharmacology [MESH] |Aortic Aneurysm, Abdominal/chemically induced/*drug therapy/metabolism [MESH] |Apolipoproteins E/*physiology [MESH] |Blotting, Western [MESH] |Cells, Cultured [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation, Enzymologic/*drug effects [MESH] |Male [MESH] |Matrix Metalloproteinase 2/*metabolism [MESH] |Matrix Metalloproteinase 9/*metabolism [MESH] |Melatonin/*pharmacology [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Myocytes, Smooth Muscle/drug effects/metabolism [MESH] |RNA, Messenger/genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH]Melatonin attenuates angiotensin II-induced abdominal aortic aneurysm (epmc).pdf DeepDyve Pubget Overpricing