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10.1016/j.bbagen.2016.05.017 http://scihub22266oqcxt.onion/10.1016/j.bbagen.2016.05.017 C5362166!5362166!27208426     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta 2016 ; 1860 (12): 2802-15 Nephropedia Template TP {{tp|p=27208426|t=2016. Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress?,?? |pdf=|usr=}}{{27208426}} gab.com Text Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress , JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=27208426 #FOAvip Background: Oxidant stress is arguably a universal feature in toxicology. Research studies on the role of oxidant stress induced by xenobiotic exposures have typically relied on the identification of damaged biomolecules using a variety of conventional biochemical and molecular techniques. However, there is increasing evidence that low-level exposure to a variety of toxicants dysregulates cellular physiology by interfering with redox-dependent processes. Scope of review: The study of events involved in redox toxicology requires methodology capable of detecting transient modifications at relatively low signal strength. This article reviews the advantages of live-cell imaging for redox toxicology studies. Major conclusions: Toxicological studies with xenobiotics of supra-physiological reactivity require careful consideration when using fluorogenic sensors in order to avoid potential artifacts and false negatives. Fortunately, experiments conducted for the purpose of validating the use of these sensors in toxicological applications often yield unexpected insights into the mechanisms through which xenobiotic exposure induces oxidant stress. General significance: Live-cell imaging using a new generation of small molecule and genetically encoded fluorophores with excellent sensitivity and specificity affords unprecedented spatiotemporal resolution that is optimal for redox toxicology studies. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. Twit Text FOAVip Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress , ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=27208426 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27208426 #FOAvip English Wikipedia <ref>{{Cite pmid|27208426}}</ref> Live-cell imaging approaches for the investigation of xenobiotic-induced oxidant stress?,?? #MMPMID27208426 Wages PA; Cheng WY; Gibbs-Flournoy E; Samet JM Biochim Biophys Acta 2016[Dec]; 1860 (12): 2802-15 PMID27208426show ga Background: Oxidant stress is arguably a universal feature in toxicology. Research studies on the role of oxidant stress induced by xenobiotic exposures have typically relied on the identification of damaged biomolecules using a variety of conventional biochemical and molecular techniques. However, there is increasing evidence that low-level exposure to a variety of toxicants dysregulates cellular physiology by interfering with redox-dependent processes. Scope of review: The study of events involved in redox toxicology requires methodology capable of detecting transient modifications at relatively low signal strength. This article reviews the advantages of live-cell imaging for redox toxicology studies. Major conclusions: Toxicological studies with xenobiotics of supra-physiological reactivity require careful consideration when using fluorogenic sensors in order to avoid potential artifacts and false negatives. Fortunately, experiments conducted for the purpose of validating the use of these sensors in toxicological applications often yield unexpected insights into the mechanisms through which xenobiotic exposure induces oxidant stress. General significance: Live-cell imaging using a new generation of small molecule and genetically encoded fluorophores with excellent sensitivity and specificity affords unprecedented spatiotemporal resolution that is optimal for redox toxicology studies. This article is part of a Special Issue entitled Air Pollution, edited by Wenjun Ding, Andrew J. Ghio and Weidong Wu. äLive-cell imaging approaches for the investigation of xenobiotic-induc(epmc).pdf DeepDyve Pubget Overpricing