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10.1097/INF.0000000000001450 http://scihub22266oqcxt.onion/10.1097/INF.0000000000001450 C5362110!5362110!27977555     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pediatr+Infect+Dis+J 2017 ; 36 (4): 379-83 Nephropedia Template TP {{tp|p=27977555|t=2017. Recurrent Clostridium difficile Infection in Children: Patient Risk Factors and Markers of Intestinal Inflammation |pdf=|usr=}}{{27977555}} gab.com Text Recurrent Clostridium difficile Infection in Children: Patient Risk Factors and Markers of Intestinal Inflammation JO: Pediatr Infect Dis J http://www.kidney.de/pget.php?&tw=1&pmid=27977555 #FOAvip Background: The management of Clostridium difficile infection (CDI) in children is complicated by recurrence rates of 20?30%. The identification of risk factors associated with recurrent disease might allow early recognition of those children at highest risk. Methods: Pediatric patients with CDI were identified through clinical laboratory records at two tertiary care children?s hospitals from March 2013 through May 2014. Subjects were enrolled and followed for 60 days to assess for recurrent CDI (rCDI). Blood samples were obtained at enrollment to evaluate host interleukin (IL-) 8 polymorphisms and anti-toxin A antibody levels; stool samples were obtained for inflammatory markers (lactoferrin, calprotectin, IL-8), and C. difficile ribotype 027 strain status. Thirty days post enrollment another serum sample was obtained to compare antibody responses. Results: Of the 28 pediatric patients enrolled, 27 completed follow-up and 8 (30%) experienced rCDI. At enrollment, children with malignancy had significantly lower stool calprotectin, lactoferrin, and IL-8 than those without malignancy. There was a trend toward increased stool inflammatory markers in those who later developed rCDI. The IL-8 A/A genotype was not associated with recurrent disease. No patients were found to have ribotype 027 or an antibody increase to toxin A. Conclusions: The rate of rCDI in our pediatric cohort was 30%. Children with rCDI had a trend toward higher fecal inflammatory markers with the initial infection and these values were lower in children with malignancy. Fecal lactoferrin, calprotectin, and IL-8 should be further studied to determine their value in predicting the risk of rCDI in children. Twit Text FOAVip Recurrent Clostridium difficile Infection in Children: Patient Risk Factors and Markers of Intestinal Inflammation ????Pediatr Infect Dis J http://www.kidney.de/pget.php?&tw=1&pmid=27977555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27977555 #FOAvip English Wikipedia <ref>{{Cite pmid|27977555}}</ref> Recurrent Clostridium difficile Infection in Children: Patient Risk Factors and Markers of Intestinal Inflammation #MMPMID27977555 Nicholson MR; Crews JD; Starke JR; Jiang ZD; DuPont H; Edwards K Pediatr Infect Dis J 2017[Apr]; 36 (4): 379-83 PMID27977555show ga Background: The management of Clostridium difficile infection (CDI) in children is complicated by recurrence rates of 20?30%. The identification of risk factors associated with recurrent disease might allow early recognition of those children at highest risk. Methods: Pediatric patients with CDI were identified through clinical laboratory records at two tertiary care children?s hospitals from March 2013 through May 2014. Subjects were enrolled and followed for 60 days to assess for recurrent CDI (rCDI). Blood samples were obtained at enrollment to evaluate host interleukin (IL-) 8 polymorphisms and anti-toxin A antibody levels; stool samples were obtained for inflammatory markers (lactoferrin, calprotectin, IL-8), and C. difficile ribotype 027 strain status. Thirty days post enrollment another serum sample was obtained to compare antibody responses. Results: Of the 28 pediatric patients enrolled, 27 completed follow-up and 8 (30%) experienced rCDI. At enrollment, children with malignancy had significantly lower stool calprotectin, lactoferrin, and IL-8 than those without malignancy. There was a trend toward increased stool inflammatory markers in those who later developed rCDI. The IL-8 A/A genotype was not associated with recurrent disease. No patients were found to have ribotype 027 or an antibody increase to toxin A. Conclusions: The rate of rCDI in our pediatric cohort was 30%. Children with rCDI had a trend toward higher fecal inflammatory markers with the initial infection and these values were lower in children with malignancy. Fecal lactoferrin, calprotectin, and IL-8 should be further studied to determine their value in predicting the risk of rCDI in children. äRecurrent Clostridium difficile Infection in Children: Patient Risk Fa(epmc).pdf DeepDyve Pubget Overpricing