Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28344540
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Proteomics
2017 ; 14
(ä): 8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Tubulointerstitial nephritis antigen-like 1 protein is downregulated in the
placenta of pre-eclamptic women
#MMPMID28344540
Mary S
; Kulkarni MJ
; Mehendale SS
; Joshi SR
; Giri AP
Clin Proteomics
2017[]; 14
(ä): 8
PMID28344540
show ga
BACKGROUND: Tubulointerstitial nephritis antigen-like 1 protein (TINAGL1), is a
matricellular protein, known to play role in cell adhesion and cell receptor
interaction. Research related to TINAGL1 is limited to cell culture and animal
models. Demonstration of TINAGL1 as a positive regulator of angiogenesis and its
expression in the decidua of postimplantation mouse uterus, prompted us to
validate its expression in human placenta during impaired angiogenesis in
pre-eclamptic condition. METHODS: Placental tissue from normotensive (n = 25) and
pre-eclamptic (n = 25) pregnancies were used to study the differentially
expressed proteins by two-dimensional gel electrophoresis and TINAGL1 protein was
validated with Western blotting. RESULTS: A total of 55 protein spots were
differentially expressed (fold change >1.5, p < 0.05), of which 27 were
upregulated and 28 were downregulated in the pre-eclamptic placenta. TINAGL1 was
found to be downregulated in pre-eclamptic compared to normotensive pregnant
women. CONCLUSION: This is the first study reporting TINAGL1 to be present in
human placenta and differentially expressed in pre-eclamptic condition. The
functional role of TINAGL1 in association to human pregnancy needs to be explored
further.