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10.1038/srep45029 http://scihub22266oqcxt.onion/10.1038/srep45029 C5361208!5361208 !28327666     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28327666 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 45029 Nephropedia Template TP {{tp|p=28327666 |t=2017. Hypoxia induces H19 expression through direct and indirect Hif-1? activity, promoting oncogenic effects in glioblastoma |pdf=|usr=}}{{28327666 }} gab.com Text Hypoxia induces H19 expression through direct and indirect Hif-1 activity, promoting oncogenic effects in glioblastoma JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28327666 #FOAvip H19 expression is elevated in many human tumors including glioblastomas, suggesting an oncogenic role for the long noncoding RNA; yet the upregulation of H19 in glioblastomas remains unclear. Here we report that hypoxia significantly stimulated H19 expression in glioblastoma cell lines, which was related to hypoxia-inducible factors 1? (Hif-1?). Hif-1? promoted H19 expression in U87 and U251 cells. Meanwhile PTEN is an advantageous factor to affect H19 expression, through attenuating Hif-1? stability. Hif-1? also positively correlates with H19 in human glioblastoma samples depending on PTEN status. ChIP and luciferase reporter assays showed that Hif-1? induced H19 transcription through directly binding to the H19 promoter. Furthermore, Hif-1? upregulated specific protein 1 (SP1) expression in glioblastomas cells in vitro and in vivo, and SP1 also strongly interacted with the H19 promoter to promote H19 expression under hypoxia. We also showed that H19 acts as a molecular sponge that binds miR-181d, relieving inhibition of ?-catenin expression. Therefore, H19 participates in hypoxia-driven migration and invasion in glioblastoma cells. In summary, our results uncover the mechanisms that stimulate H19 expression under hypoxia to promote malignant effects in glioblastomas and suggest H19 might be a promising therapeutic target. Twit Text FOAVip Hypoxia induces H19 expression through direct and indirect Hif-1 activity, promoting oncogenic effects in glioblastoma ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28327666 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28327666 #FOAvip English Wikipedia <ref>{{Cite pmid|28327666 }}</ref> Hypoxia induces H19 expression through direct and indirect Hif-1? activity, promoting oncogenic effects in glioblastoma #MMPMID28327666 Wu W ; Hu Q ; Nie E ; Yu T ; Wu Y ; Zhi T ; Jiang K ; Shen F ; Wang Y ; Zhang J ; You Y Sci Rep 2017[Mar]; 7 (ä): 45029 PMID28327666 show ga H19 expression is elevated in many human tumors including glioblastomas, suggesting an oncogenic role for the long noncoding RNA; yet the upregulation of H19 in glioblastomas remains unclear. Here we report that hypoxia significantly stimulated H19 expression in glioblastoma cell lines, which was related to hypoxia-inducible factors 1? (Hif-1?). Hif-1? promoted H19 expression in U87 and U251 cells. Meanwhile PTEN is an advantageous factor to affect H19 expression, through attenuating Hif-1? stability. Hif-1? also positively correlates with H19 in human glioblastoma samples depending on PTEN status. ChIP and luciferase reporter assays showed that Hif-1? induced H19 transcription through directly binding to the H19 promoter. Furthermore, Hif-1? upregulated specific protein 1 (SP1) expression in glioblastomas cells in vitro and in vivo, and SP1 also strongly interacted with the H19 promoter to promote H19 expression under hypoxia. We also showed that H19 acts as a molecular sponge that binds miR-181d, relieving inhibition of ?-catenin expression. Therefore, H19 participates in hypoxia-driven migration and invasion in glioblastoma cells. In summary, our results uncover the mechanisms that stimulate H19 expression under hypoxia to promote malignant effects in glioblastomas and suggest H19 might be a promising therapeutic target. |*Gene Expression Regulation, Neoplastic [MESH] |Animals [MESH] |Biomarkers, Tumor [MESH] |Brain/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Transformation, Neoplastic/genetics/metabolism [MESH] |Disease Models, Animal [MESH] |Gene Expression [MESH] |Glioblastoma/*genetics/*metabolism/mortality/pathology [MESH] |Humans [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism [MESH] |Hypoxia/*genetics/*metabolism [MESH] |Mice [MESH] |MicroRNAs/genetics [MESH] |PTEN Phosphohydrolase/metabolism [MESH] |Prognosis [MESH] |Promoter Regions, Genetic [MESH] |Protein Binding [MESH] |RNA Interference [MESH] |RNA, Long Noncoding/*genetics [MESH] |Response Elements [MESH] |Sp1 Transcription Factor/metabolism [MESH]Hypoxia induces H19 expression through direct and indirect Hif-1? acti(epmc).pdf DeepDyve Pubget Overpricing