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10.1038/srep45184 http://scihub22266oqcxt.onion/10.1038/srep45184 C5361111!5361111 !28327594     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28327594 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 45184 Nephropedia Template TP {{tp|p=28327594 |t=2017. Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC) |pdf=|usr=}}{{28327594 }} gab.com Text Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC) JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28327594 #FOAvip Aspirin induces apoptotic cell death in various cancer cell lines. Here we showed that silencing of VDAC1 protected HeLa cells from aspirin-induced cell death. Compared to the wild type cells, VDAC1 knocked down cells showed lesser change of mitochondrial membrane potential (??(m)), upon aspirin treatment. Aspirin augmented ATP and ionomycin-induced mitochondrial Ca(2+) uptake which was abolished in VDAC1 knocked down cells. Aspirin dissociated bound hexokinase II (HK-II) from mitochondria. Further, aspirin promoted the closure of recombinant human VDAC1, reconstituted in planar lipid bilayer. Taken together, these results imply that VDAC1 serves as a novel target for aspirin. Modulation of VDAC1 is possibly associated with the cell death and anticancer effects of aspirin. Twit Text FOAVip Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC) ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28327594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28327594 #FOAvip English Wikipedia <ref>{{Cite pmid|28327594 }}</ref> Aspirin induces cell death by directly modulating mitochondrial voltage-dependent anion channel (VDAC) #MMPMID28327594 Tewari D ; Majumdar D ; Vallabhaneni S ; Bera AK Sci Rep 2017[Mar]; 7 (ä): 45184 PMID28327594 show ga Aspirin induces apoptotic cell death in various cancer cell lines. Here we showed that silencing of VDAC1 protected HeLa cells from aspirin-induced cell death. Compared to the wild type cells, VDAC1 knocked down cells showed lesser change of mitochondrial membrane potential (??(m)), upon aspirin treatment. Aspirin augmented ATP and ionomycin-induced mitochondrial Ca(2+) uptake which was abolished in VDAC1 knocked down cells. Aspirin dissociated bound hexokinase II (HK-II) from mitochondria. Further, aspirin promoted the closure of recombinant human VDAC1, reconstituted in planar lipid bilayer. Taken together, these results imply that VDAC1 serves as a novel target for aspirin. Modulation of VDAC1 is possibly associated with the cell death and anticancer effects of aspirin. |Adenosine Triphosphate/metabolism [MESH] |Animals [MESH] |Anti-Inflammatory Agents, Non-Steroidal/*pharmacology [MESH] |Apoptosis/*drug effects [MESH] |Aspirin/*pharmacology [MESH] |Calcium/metabolism [MESH] |HeLa Cells [MESH] |Hexokinase/metabolism [MESH] |Humans [MESH] |Membrane Potential, Mitochondrial [MESH] |Mitochondria/*drug effects/metabolism [MESH] |Rats [MESH]Aspirin induces cell death by directly modulating mitochondrial voltag(epmc).pdf DeepDyve Pubget Overpricing