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Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Mediators+Inflamm 2017 ; 2017 (ä): ä Nephropedia Template TP
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Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A?42 through Nrf2-Related Inflammatory Response #MMPMID28373747
Seo JY; Pyo E; An JP; Kim J; Sung SH; Oh WK
Mediators Inflamm 2017[]; 2017 (ä): ä PMID28373747show ga
Therapeutic approach of Alzheimer's disease (AD) has been gradually diversified. We examined the therapeutic and preventive potential of andrographolide, which is a lactone diterpenoid from Andrographis paniculata, and focused on the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects and the inhibitory activity of amyloid beta (A?)42-induced microglial activation related to Nrf2 and nuclear factor ?B (NF-?B)-mediated inflammatory responses. Andrographolide induced the expression and translocation of Nrf2 from the cytoplasm to the nucleus, thereby activating antioxidant response element (ARE) gene transcription and HO-1 expression in murine hippocampal HT22 cells. Andrographolide eliminated intracellular A?42 in BV-2 cells and decreased the production of interleukin (IL)-6, IL-1?, prostaglandin (PG)E2, and nitric oxide (NO) because of artificial phagocytic A?42. It decreased pNF-?B accumulation in the nucleus and the expression of inducible nitric oxide synthase (i-NOS) and cyclooxygenase II (COX-II) in the microglial BV-2 cell line. In summary, andrographolide activates Nrf2-mediated HO-1 expression and inhibits A?42-overexpressed microglial BV-2 cell activation. These results suggested that andrographolide might have the potential for further examination of the therapeutics of AD.
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Mediators+Inflamm 2017 ; 2017 (ä): ä
