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10.1155/2017/5906189 http://scihub22266oqcxt.onion/10.1155/2017/5906189 C5360972!5360972 !28373747     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 276.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28373747 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mediators+Inflamm 2017 ; 2017 (ä): 5906189 Nephropedia Template TP {{tp|p=28373747 |t=2017. Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A?(42) through Nrf2-Related Inflammatory Response |pdf=|usr=}}{{28373747 }} gab.com Text Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A (42) through Nrf2-Related Inflammatory Response JO: Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=28373747 #FOAvip Therapeutic approach of Alzheimer's disease (AD) has been gradually diversified. We examined the therapeutic and preventive potential of andrographolide, which is a lactone diterpenoid from Andrographis paniculata, and focused on the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects and the inhibitory activity of amyloid beta (A?)(42)-induced microglial activation related to Nrf2 and nuclear factor ?B (NF-?B)-mediated inflammatory responses. Andrographolide induced the expression and translocation of Nrf2 from the cytoplasm to the nucleus, thereby activating antioxidant response element (ARE) gene transcription and HO-1 expression in murine hippocampal HT22 cells. Andrographolide eliminated intracellular A?(42) in BV-2 cells and decreased the production of interleukin (IL)-6, IL-1?, prostaglandin (PG)E(2), and nitric oxide (NO) because of artificial phagocytic A?(42). It decreased pNF-?B accumulation in the nucleus and the expression of inducible nitric oxide synthase (i-NOS) and cyclooxygenase II (COX-II) in the microglial BV-2 cell line. In summary, andrographolide activates Nrf2-mediated HO-1 expression and inhibits A?(42)-overexpressed microglial BV-2 cell activation. These results suggested that andrographolide might have the potential for further examination of the therapeutics of AD. Twit Text FOAVip Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A (42) through Nrf2-Related Inflammatory Response ????Mediators Inflamm http://www.kidney.de/pget.php?&tw=1&pmid=28373747 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28373747 #FOAvip English Wikipedia <ref>{{Cite pmid|28373747 }}</ref> Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells and Suppresses Microglial Activation by A?(42) through Nrf2-Related Inflammatory Response #MMPMID28373747 Seo JY ; Pyo E ; An JP ; Kim J ; Sung SH ; Oh WK Mediators Inflamm 2017[]; 2017 (ä): 5906189 PMID28373747 show ga Therapeutic approach of Alzheimer's disease (AD) has been gradually diversified. We examined the therapeutic and preventive potential of andrographolide, which is a lactone diterpenoid from Andrographis paniculata, and focused on the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects and the inhibitory activity of amyloid beta (A?)(42)-induced microglial activation related to Nrf2 and nuclear factor ?B (NF-?B)-mediated inflammatory responses. Andrographolide induced the expression and translocation of Nrf2 from the cytoplasm to the nucleus, thereby activating antioxidant response element (ARE) gene transcription and HO-1 expression in murine hippocampal HT22 cells. Andrographolide eliminated intracellular A?(42) in BV-2 cells and decreased the production of interleukin (IL)-6, IL-1?, prostaglandin (PG)E(2), and nitric oxide (NO) because of artificial phagocytic A?(42). It decreased pNF-?B accumulation in the nucleus and the expression of inducible nitric oxide synthase (i-NOS) and cyclooxygenase II (COX-II) in the microglial BV-2 cell line. In summary, andrographolide activates Nrf2-mediated HO-1 expression and inhibits A?(42)-overexpressed microglial BV-2 cell activation. These results suggested that andrographolide might have the potential for further examination of the therapeutics of AD. |Active Transport, Cell Nucleus/drug effects [MESH] |Amyloid beta-Peptides/genetics/metabolism [MESH] |Animals [MESH] |Blotting, Western [MESH] |Carboxylic Ester Hydrolases/genetics/*metabolism [MESH] |Cell Line [MESH] |Dinoprostone/metabolism [MESH] |Diterpenes/*pharmacology [MESH] |Heme Oxygenase-1/genetics/*metabolism [MESH] |Immunohistochemistry [MESH] |Inflammation/genetics/metabolism [MESH] |Interleukin-1beta/metabolism [MESH] |Interleukin-6/metabolism [MESH] |Kelch-Like ECH-Associated Protein 1/genetics/*metabolism [MESH] |Membrane Proteins/genetics/*metabolism [MESH] |Mice [MESH] |Microglia/drug effects/metabolism [MESH] |Molecular Structure [MESH] |NF-E2-Related Factor 2/genetics/*metabolism [MESH] |Peptide Fragments/genetics/metabolism [MESH] |Real-Time Polymerase Chain Reaction [MESH]Andrographolide Activates Keap1/Nrf2/ARE/HO-1 Pathway in HT22 Cells an(epmc).pdf DeepDyve Pubget Overpricing