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10.3748/wjg.v23.i11.1944 http://scihub22266oqcxt.onion/10.3748/wjg.v23.i11.1944 C5360635!5360635!28373760     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       World+J+Gastroenterol 2017 ; 23 (11): 1944-53 Nephropedia Template TP {{tp|p=28373760|t=2017. Role of autophagy in the pathogenesis of inflammatory bowel disease |pdf=|usr=}}{{28373760}} gab.com Text Role of autophagy in the pathogenesis of inflammatory bowel disease JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28373760 #FOAvip Inflammatory bowel disease (IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune system. Recently, some studies provided strong evidence that the process of autophagy affects several aspects of mucosal immune responses. Autophagy is a cellular stress response that plays key roles in physiological processes, such as innate and adaptive immunity, adaptation to starvation, degradation of aberrant proteins or organelles, antimicrobial defense, and protein secretion. Dysfunctional autophagy is recognized as a contributing factor in many chronic inflammatory diseases, including IBD. Autophagy plays multiple roles in IBD pathogenesis by altering processes that include intracellular bacterial killing, antimicrobial peptide secretion by Paneth cells, goblet cell function, proinflammatory cytokine production by macrophages, antigen presentation by dendritic cells, and the endoplasmic reticulum stress response in enterocytes. Recent studies have identified susceptibility genes involved in autophagy, such as NOD2, ATG16L1, and IRGM, and active research is ongoing all over the world. The aim of this review is a systematic appraisal of the current literature to provide a better understanding of the role of autophagy in the pathogenesis of IBD. Understanding these mechanisms will bring about new strategies for the treatment and prevention of IBD. Twit Text FOAVip Role of autophagy in the pathogenesis of inflammatory bowel disease ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28373760 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28373760 #FOAvip English Wikipedia <ref>{{Cite pmid|28373760}}</ref> Role of autophagy in the pathogenesis of inflammatory bowel disease #MMPMID28373760 Iida T; Onodera K; Nakase H World J Gastroenterol 2017[Mar]; 23 (11): 1944-53 PMID28373760show ga Inflammatory bowel disease (IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune system. Recently, some studies provided strong evidence that the process of autophagy affects several aspects of mucosal immune responses. Autophagy is a cellular stress response that plays key roles in physiological processes, such as innate and adaptive immunity, adaptation to starvation, degradation of aberrant proteins or organelles, antimicrobial defense, and protein secretion. Dysfunctional autophagy is recognized as a contributing factor in many chronic inflammatory diseases, including IBD. Autophagy plays multiple roles in IBD pathogenesis by altering processes that include intracellular bacterial killing, antimicrobial peptide secretion by Paneth cells, goblet cell function, proinflammatory cytokine production by macrophages, antigen presentation by dendritic cells, and the endoplasmic reticulum stress response in enterocytes. Recent studies have identified susceptibility genes involved in autophagy, such as NOD2, ATG16L1, and IRGM, and active research is ongoing all over the world. The aim of this review is a systematic appraisal of the current literature to provide a better understanding of the role of autophagy in the pathogenesis of IBD. Understanding these mechanisms will bring about new strategies for the treatment and prevention of IBD. äRole of autophagy in the pathogenesis of inflammatory bowel disease (epmc).pdf DeepDyve Pubget Overpricing