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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Ann+Transl+Med
2017 ; 5
(5
): 100
Nephropedia Template TP
gab.com Text
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English Wikipedia
Surgical prophylaxis with gentamicin and acute kidney injury: a systematic review
and meta-analysis
#MMPMID28361065
Srisung W
; Teerakanok J
; Tantrachoti P
; Karukote A
; Nugent K
Ann Transl Med
2017[Mar]; 5
(5
): 100
PMID28361065
show ga
BACKGROUND: Gentamicin has been increasingly used instead of cephalosporins for
surgical prophylaxis in an attempt to reduce the rate of "Clostridium difficile"
infection. There are limited data regarding nephrotoxicity related to gentamicin
in these patients. METHODS: We have conducted a systematic review and
meta-analysis to evaluate the risk of acute kidney injury (AKI) in
gentamicin-containing surgical prophylactic regimens, compared to regimens
without gentamicin, in several types of surgery. Electronic searches were
performed using PubMed and Embase, including terms for "AKI, gentamicin, and
surgical prophylaxis" with and without MeSH/EMTREE functions. Statistical
analysis was then performed using a random-effect model; risk ratios (RR), risk
differences (RD) and heterogeneity (I(2)) were calculated. Funnel plot was used
for assessment of publication bias. RESULTS: Eleven studies with fifteen cohorts
with 18,354 patients were included in the analysis. Subgroup analysis was
performed according to surgery type. We have found that antibiotic prophylaxis
with gentamicin containing regimen has significant risk for developing
postoperative AKI in orthopedic surgery (RR 2.99; 95% CI: 1.84, 4.88). The
results were inconclusive in other types of surgery. Funnel plot indicates
potential publication bias. CONCLUSIONS: Gentamicin-induced AKI is significant in
patients undergoing orthopedic surgery. Physicians should consider risks and
benefits of using this regimen in individual patients.