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10.4049/jimmunol.1600028 http://scihub22266oqcxt.onion/10.4049/jimmunol.1600028 C5360510!5360510!28219888     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2017 ; 198 (7): 2568-77 Nephropedia Template TP {{tp|p=28219888|t=2017. CD74 deficiency mitigates systemic lupus erythematosus-like autoimmunity and pathological findings in mice |pdf=|usr=}}{{28219888}} gab.com Text CD74 deficiency mitigates systemic lupus erythematosus-like autoimmunity and pathological findings in mice JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28219888 #FOAvip CD74 mediates major histocompatibility complex class-II (MHC-II) antigenic peptide loading and presentation, and plays an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). C57BL/6 Faslpr mice that develop spontaneous lupus-like autoimmunity and pathology showed elevated CD74 expression in the inflammatory cell infiltrates and the adjacent tubular epithelial cells (TECs) in kidneys affected by lupus nephritis, but negligible levels in kidneys from age-matched wild-type (WT) mice. The inflammatory cytokines IFN-g or IL6 induced CD74 expression in kidney TECs in vitro. The presence of kidney TECs from Faslpr mice, rather than from WT mice, produced significantly stronger histones, dsDNA, and ribonucleoprotein (RNP)-Smith antigen (Sm) complex RNP/Sm-induced CD4+ T-cell activation. Splenocytes from CD74-deficient FaslprCd74?/? mice had muted responses in a mixed lymphocyte reaction and to the autoantigen histones. Compared to FaslprCd74+/+ mice, FaslprCd74?/? mice had reduced kidney and spleen sizes, splenic activated T cells and B cells, serum IgG and autoantibodies, urine albumin to creatinine ratio, kidney PAS (Periodic acid-Schiff) score, IgG and C3 deposition, and reduced serum IL6 and IL17A but increased serum IL2 and TGF-? levels. Study of chronic graft-versus-host (cGVH) C57BL/6 mice that received donor splenocytes from bm12 mice and those that received syngeneic donor splenocytes yielded similar observations. CD74 deficiency reduced lupus-like autoimmunity and kidney pathology in cGVH mice. This investigation establishes the direct participation of CD74 in autoimmunity and highlights a potential role of CD74 in kidney TECs together with professional antigen-presenting cells in SLE. Twit Text FOAVip CD74 deficiency mitigates systemic lupus erythematosus-like autoimmunity and pathological findings in mice ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28219888 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28219888 #FOAvip English Wikipedia <ref>{{Cite pmid|28219888}}</ref> CD74 deficiency mitigates systemic lupus erythematosus-like autoimmunity and pathological findings in mice #MMPMID28219888 Zhou Y; Chen H; Liu L; Yu X; Sukhova GK; Yang M; Zhang L; Kyttaris VC; Tsokos GC; Stillman IE; Ichimura T; Bonventre JV; Libby P; Shi GP J Immunol 2017[Apr]; 198 (7): 2568-77 PMID28219888show ga CD74 mediates major histocompatibility complex class-II (MHC-II) antigenic peptide loading and presentation, and plays an important role in the pathogenesis of autoimmune diseases, including systemic lupus erythematosus (SLE). C57BL/6 Faslpr mice that develop spontaneous lupus-like autoimmunity and pathology showed elevated CD74 expression in the inflammatory cell infiltrates and the adjacent tubular epithelial cells (TECs) in kidneys affected by lupus nephritis, but negligible levels in kidneys from age-matched wild-type (WT) mice. The inflammatory cytokines IFN-g or IL6 induced CD74 expression in kidney TECs in vitro. The presence of kidney TECs from Faslpr mice, rather than from WT mice, produced significantly stronger histones, dsDNA, and ribonucleoprotein (RNP)-Smith antigen (Sm) complex RNP/Sm-induced CD4+ T-cell activation. Splenocytes from CD74-deficient FaslprCd74?/? mice had muted responses in a mixed lymphocyte reaction and to the autoantigen histones. Compared to FaslprCd74+/+ mice, FaslprCd74?/? mice had reduced kidney and spleen sizes, splenic activated T cells and B cells, serum IgG and autoantibodies, urine albumin to creatinine ratio, kidney PAS (Periodic acid-Schiff) score, IgG and C3 deposition, and reduced serum IL6 and IL17A but increased serum IL2 and TGF-? levels. Study of chronic graft-versus-host (cGVH) C57BL/6 mice that received donor splenocytes from bm12 mice and those that received syngeneic donor splenocytes yielded similar observations. CD74 deficiency reduced lupus-like autoimmunity and kidney pathology in cGVH mice. This investigation establishes the direct participation of CD74 in autoimmunity and highlights a potential role of CD74 in kidney TECs together with professional antigen-presenting cells in SLE. äCD74 deficiency mitigates systemic lupus erythematosus-like autoimmuni(epmc).pdf DeepDyve Pubget Overpricing