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10.4049/jimmunol.1600281 http://scihub22266oqcxt.onion/10.4049/jimmunol.1600281 C5360485!5360485!28235864     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2017 ; 198 (7): 2602-11 Nephropedia Template TP {{tp|p=28235864|t=2017. BAFF induces tertiary lymphoid structures and positions T cells within the glomeruli during lupus nephritis1 |pdf=|usr=}}{{28235864}} gab.com Text BAFF induces tertiary lymphoid structures and positions T cells within the glomeruli during lupus nephritis1 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28235864 #FOAvip Tissue-specific immune responses play an important role in the pathology of autoimmune diseases. In systemic lupus erythematosus (SLE), deposits of IgG-immune complexes and the activation of complement in the kidney have long been thought to promote inflammation and lupus nephritis. However, the events that localize cells in non-lymphoid tertiary organs and sustain tissue-specific immune responses remain undefined. In this manuscript, we show that B cell activating factor of the TNF family (BAFF) promotes events leading to lupus nephritis. Using an inducible model of SLE, we found that passive transfer of anti-nucleosome IgG into AID?/?MRL/lpr mice elevated autoantibody levels and promoted lupus nephritis by inducing BAFF production in the kidneys, and the formation of renal tertiary lymphoid structures (TLSs). Reducing BAFF in vivo prevented the formation of TLSs and lupus nephritis; however, it did not reduce immune cell infiltrates, or the deposits of IgG and complement in the kidney. Mechanistically, lowering BAFF levels also diminished the number of T cells positioned inside the glomeruli and reduced inflammation. Thus, BAFF plays a previously unappreciated role in lupus nephritis by inducing renal TLSs and regulating the position of T cells within the glomeruli. Twit Text FOAVip BAFF induces tertiary lymphoid structures and positions T cells within the glomeruli during lupus nephritis1 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28235864 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28235864 #FOAvip English Wikipedia <ref>{{Cite pmid|28235864}}</ref> BAFF induces tertiary lymphoid structures and positions T cells within the glomeruli during lupus nephritis1 #MMPMID28235864 Kang S; Fedoriw Y; Brenneman EK; Truong YK; Kikly K; Vilen BJ J Immunol 2017[Apr]; 198 (7): 2602-11 PMID28235864show ga Tissue-specific immune responses play an important role in the pathology of autoimmune diseases. In systemic lupus erythematosus (SLE), deposits of IgG-immune complexes and the activation of complement in the kidney have long been thought to promote inflammation and lupus nephritis. However, the events that localize cells in non-lymphoid tertiary organs and sustain tissue-specific immune responses remain undefined. In this manuscript, we show that B cell activating factor of the TNF family (BAFF) promotes events leading to lupus nephritis. Using an inducible model of SLE, we found that passive transfer of anti-nucleosome IgG into AID?/?MRL/lpr mice elevated autoantibody levels and promoted lupus nephritis by inducing BAFF production in the kidneys, and the formation of renal tertiary lymphoid structures (TLSs). Reducing BAFF in vivo prevented the formation of TLSs and lupus nephritis; however, it did not reduce immune cell infiltrates, or the deposits of IgG and complement in the kidney. Mechanistically, lowering BAFF levels also diminished the number of T cells positioned inside the glomeruli and reduced inflammation. Thus, BAFF plays a previously unappreciated role in lupus nephritis by inducing renal TLSs and regulating the position of T cells within the glomeruli. äBAFF induces tertiary lymphoid structures and positions T cells within(epmc).pdf DeepDyve Pubget Overpricing