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10.4049/jimmunol.1601462 http://scihub22266oqcxt.onion/10.4049/jimmunol.1601462 C5360474!5360474!28202617     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2017 ; 198 (7): 2649-60 Nephropedia Template TP {{tp|p=28202617|t=2017. The bacterial peptidoglycan sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection |pdf=|usr=}}{{28202617}} gab.com Text The bacterial peptidoglycan sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28202617 #FOAvip Nucleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans. Whilst studies have addressed the role of NOD proteins in innate immune responses, little attention has been given to their impact on the developing adaptive immune system. We have assessed the roles of NOD1 and NOD2 deficiency on T cell development in mice. Our results demonstrate that NOD1 and NOD2 promote the positive selection/maturation of CD8 SP thymocytes in a thymocyte intrinsic manner. TCR-mediated ERK phosphorylation is significantly reduced in the absence of NOD proteins, but RIP2 is not involved in CD8 SP thymocyte selection or ERK signaling. Commensal bacteria free animals have thymocyte maturation defects and exogenous NOD ligands can enhance thymocyte maturation in culture. These results raise the intriguing possibility that abnormal lymphocyte responses observed in NOD-dependent inflammatory diseases are not driven solely by microbial signals in the gut, but may also involve intrinsic lymphocyte defects resulting from impaired CD8 T cell thymic development. Twit Text FOAVip The bacterial peptidoglycan sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28202617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28202617 #FOAvip English Wikipedia <ref>{{Cite pmid|28202617}}</ref> The bacterial peptidoglycan sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection #MMPMID28202617 Martinic MM; Caminschi I; O?Keeffe M; Thinnes TC; Grumont R; Gerondakis S; McKay DB; Nemazee D; Gavin AL J Immunol 2017[Apr]; 198 (7): 2649-60 PMID28202617show ga Nucleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans. Whilst studies have addressed the role of NOD proteins in innate immune responses, little attention has been given to their impact on the developing adaptive immune system. We have assessed the roles of NOD1 and NOD2 deficiency on T cell development in mice. Our results demonstrate that NOD1 and NOD2 promote the positive selection/maturation of CD8 SP thymocytes in a thymocyte intrinsic manner. TCR-mediated ERK phosphorylation is significantly reduced in the absence of NOD proteins, but RIP2 is not involved in CD8 SP thymocyte selection or ERK signaling. Commensal bacteria free animals have thymocyte maturation defects and exogenous NOD ligands can enhance thymocyte maturation in culture. These results raise the intriguing possibility that abnormal lymphocyte responses observed in NOD-dependent inflammatory diseases are not driven solely by microbial signals in the gut, but may also involve intrinsic lymphocyte defects resulting from impaired CD8 T cell thymic development. äThe bacterial peptidoglycan sensing molecules NOD1 and NOD2 promote CD(epmc).pdf DeepDyve Pubget Overpricing