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10.7554/eLife.21130 http://scihub22266oqcxt.onion/10.7554/eLife.21130 C5360446!5360446!28323616     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28323616|t=2017. YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis |pdf=|usr=}}{{28323616}} gab.com Text YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28323616 #FOAvip Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activity is removed. This suggests that YAP controls local epithelial cell properties. In support of this model, mechanical force production is compromised and cell proliferation is reduced in Yap mutant lungs. We propose that defective force generation and insufficient epithelial cell number underlie the branching defects. Through genomic analysis, we also uncovered a feedback control of pMLC levels, which is critical for mechanical force production, likely through the direct induction of multiple regulators by YAP. Our work provides a molecular pathway that could control epithelial cell properties required for proper morphogenetic movement and pattern formation.DOI:http://dx.doi.org/10.7554/eLife.21130.001 Twit Text FOAVip YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28323616 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28323616 #FOAvip English Wikipedia <ref>{{Cite pmid|28323616}}</ref> YAP is essential for mechanical force production and epithelial cell proliferation during lung branching morphogenesis #MMPMID28323616 Lin C; Yao E; Zhang K; Jiang X; Croll S; Thompson-Peer K; Chuang PT eLife 2017[]; 6 (ä): ä PMID28323616show ga Branching morphogenesis is a fundamental program for tissue patterning. We show that active YAP, a key mediator of Hippo signaling, is distributed throughout the murine lung epithelium and loss of epithelial YAP severely disrupts branching. Failure to branch is restricted to regions where YAP activity is removed. This suggests that YAP controls local epithelial cell properties. In support of this model, mechanical force production is compromised and cell proliferation is reduced in Yap mutant lungs. We propose that defective force generation and insufficient epithelial cell number underlie the branching defects. Through genomic analysis, we also uncovered a feedback control of pMLC levels, which is critical for mechanical force production, likely through the direct induction of multiple regulators by YAP. Our work provides a molecular pathway that could control epithelial cell properties required for proper morphogenetic movement and pattern formation.DOI:http://dx.doi.org/10.7554/eLife.21130.001 äYAP is essential for mechanical force production and epithelial cell p(epmc).pdf DeepDyve Pubget Overpricing