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Efficacy of Intravenous Iron Sucrose in Hemodialysis Patients with Restless Legs
Syndrome (RLS): A Randomized, Placebo-Controlled Study
#MMPMID28285317
Deng Y
; Wu J
; Jia Q
Med Sci Monit
2017[Mar]; 23
(?): 1254-1260
PMID28285317
show ga
BACKGROUND Restless legs syndrome (RLS) is a common disorder in hemodialysis (HD)
patients that causes sleep disturbances and diminished quality of life. Because
iron deficiency has been implicated in the pathogenesis of RLS, we sought to
investigate the effects of intravenous (IV) iron sucrose on symptoms of RLS in HD
patients. MATERIAL AND METHODS The study was a randomized, placebo-controlled
study of 1000 mg iron sucrose versus normal saline as placebo. Patients were
evaluated at baseline and 2 weeks after the last injection. The severity of RLS
was assessed using the International RLS Study Group rating scale (IRLS). Blood
samples were taken to measure iron parameters reflecting the iron status,
including serum ferritin (SF) concentration, percentage transferrin saturation
(TSAT%) and hemoglobin (Hb), and other biochemical parameters as safety
assessments, including creatinine (Cr), urea, intact parathyroid hormone (iPTH),
and the index of urea clearance (Kt/V). Adverse events were monitored in all
subjects during the period of infusion. RESULTS After 2 weeks, IRLS scores
decreased more in the IV-iron group (-7.38±2.03) than in the placebo group
(-0.81±2.61) (P=0.000). Serum ferritin, TSAT, and hemoglobin increased more in
the IV-iron group (227.63±77.64 µg/L; 26.06±7.77%; 13.98±3.62g/L, respectively)
than in the placebo group (SF, p=0.000; TSAT, p=0.000; Hb, p=0.000,
respectively). There were no significant differences between IV-iron and placebo
groups in Cr, urea, iPTH, and Kt/V. No adverse effects were observed in the
study. CONCLUSIONS IV iron sucrose is a safe and effective treatment for reducing
RLS symptoms in HD patients over the short-term.
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